Literature DB >> 19338743

Cathepsin K: a therapeutic target for bone diseases.

Qingxiao Zhao1, Yanping Jia, Yongtao Xiao.   

Abstract

Cathepsin K is a member of the papain family of cysteine proteases and is highly expressed in osteoclasts that mediate bone resorption. In this review, some of the known features of cathepsin K such as structure, function in bone resorption, gene regulation and its roles in physiological or pathophysiological processes are highlighted.

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Year:  2009        PMID： 19338743     DOI： 10.1016/j.bbrc.2009.01.139

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes.

Authors:  Se Hwan Mun; Na Young Ko; Hyuk Soon Kim; Jie Wan Kim; Do Kyun Kim; A-Ram Kim; Seung Hyun Lee; Yong-Gil Kim; Chang Keun Lee; Seoung Hoon Lee; Bo Kyung Kim; Michael A Beaven; Young Mi Kim; Wahn Soo Choi
Journal:  Cell Mol Life Sci       Date:  2010-06-08       Impact factor: 9.261

2.  Potential role of cathepsin K in the pathophysiology of mucopolysaccharidoses.

Authors:  Susan Wilson; Dieter Brömme
Journal:  J Pediatr Rehabil Med       Date:  2010

3.  Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer.

Authors:  Aimalie L Hardaway; Mackenzie K Herroon; Erandi Rajagurubandara; Izabela Podgorski
Journal:  Clin Exp Metastasis       Date:  2015-03-24       Impact factor: 5.150

4.  Peptide Decoration of Nanovehicles to Achieve Active Targeting and Pathology-Responsive Cellular Uptake for Bone Metastasis Chemotherapy.

Authors:  Xuli Wang; Ye Yang; Huizhen Jia; Wanjian Jia; Scott Miller; Beth Bowman; Jun Feng; Fenghuang Zhan
Journal:  Biomater Sci       Date:  2014-04-14       Impact factor: 6.843

Review 5.  [Cathepsin K antagonists: preclinical and clinical data].

Authors:  Marion Gamsjäger; Heinrich Resch
Journal:  Wien Med Wochenschr       Date:  2015-01-09

6.  High cathepsin A protein expression predicts poor prognosis and tumor recurrence of hepatocellular carcinoma patients after curative hepatectomy.

Authors:  Laibang Luo; Xuyang Wang; Huaxiang Wang; Chengkai Yang; Youfu Zhang; Xinchang Li; Zhidan Xu
Journal:  Am J Cancer Res       Date:  2022-08-15       Impact factor: 5.942

Review 7.  Cathepsins mediate tumor metastasis.

Authors:  Gong-Jun Tan; Zheng-Ke Peng; Jin-Ping Lu; Fa-Qing Tang
Journal:  World J Biol Chem       Date:  2013-11-26

Review 8.  Clinical and animal research findings in pycnodysostosis and gene mutations of cathepsin K from 1996 to 2011.

Authors:  Yang Xue; Tao Cai; Songtao Shi; Weiguang Wang; Yanli Zhang; Tianqiu Mao; Xiaohong Duan
Journal:  Orphanet J Rare Dis       Date:  2011-05-10       Impact factor: 4.123

9.  Differential gene expression from microarray analysis distinguishes woven and lamellar bone formation in the rat ulna following mechanical loading.

Authors:  Jennifer A McKenzie; Elise C Bixby; Matthew J Silva
Journal:  PLoS One       Date:  2011-12-22       Impact factor: 3.240

10.  Mast Cells Differentiated in Synovial Fluid and Resident in Osteophytes Exalt the Inflammatory Pathology of Osteoarthritis.

Authors:  Priya Kulkarni; Abhay Harsulkar; Anne-Grete Märtson; Siim Suutre; Aare Märtson; Sulev Koks
Journal:  Int J Mol Sci       Date:  2022-01-04       Impact factor: 5.923
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