| Literature DB >> 19337569 |
Abstract
Mice have mainly been used in ovarian cancer research as immunodeficient hosts for cell lines derived from the primary tumors and ascites of ovarian cancer patients. These xenograft models have provided a valuable system for pre-clinical trials, however, the genetic complexity of human tumors has precluded the understanding of key events that drive metastatic dissemination. Recently developed immunocompetent, genetically defined mouse models of epithelial ovarian cancer represent significant improvements in the modeling of metastatic disease.Entities:
Year: 2006 PMID: 19337569 PMCID: PMC2662599 DOI: 10.1016/j.ddmod.2006.05.006
Source DB: PubMed Journal: Drug Discov Today Dis Models ISSN: 1740-6757