Literature DB >> 19336541

Absence of deleterious palladin mutations in patients with familial pancreatic cancer.

Alison P Klein1, Michael Borges, Margaret Griffith, Kieran Brune, Seung-Mo Hong, Noriyuki Omura, Ralph H Hruban, Michael Goggins.   

Abstract

It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.

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Year:  2009        PMID： 19336541      PMCID： PMC2824557          DOI： 10.1158/1055-9965.EPI-09-0056

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  27 in total

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Authors:  Detlef K Bartsch; Thomas M Gress; Peter Langer
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Journal:  Cancer       Date:  2011-09-01       Impact factor: 6.860

Review 6.  Update on familial pancreatic cancer.

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Review 8.  Current status of molecular markers for early detection of sporadic pancreatic cancer.

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