Dieter D'hoedt1, Daniel Bertrand. 1. Department of Neurosciences, CMU, Genève, Switzerland. Dhoedt@medecine.unige.ch
Abstract
BACKGROUND: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that participate in many physiological functions. Receptors result from the assembly of five homologous or heterologous subunits that form the ligand-binding site and an ionic pore. In vertebrates, 17 subunits have been identified, alpha (1 - 10), beta (1 - 4), gamma, delta and epsilon. Assembly of different subunit combinations allows a diversity of physiological and pharmacological properties. OBJECTIVE: To review the putative involvement of nAChRs in several diseases. METHODS: We discuss the expression pattern of the subunits, the pharmacological tools for distinguishing them and their role in pathogenesis. RESULTS/ CONCLUSION: Long-standing efforts in this field should soon result in the finding of new molecules that might be applicable to situations ranging from neurological diseases to immune treatments.
BACKGROUND: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that participate in many physiological functions. Receptors result from the assembly of five homologous or heterologous subunits that form the ligand-binding site and an ionic pore. In vertebrates, 17 subunits have been identified, alpha (1 - 10), beta (1 - 4), gamma, delta and epsilon. Assembly of different subunit combinations allows a diversity of physiological and pharmacological properties. OBJECTIVE: To review the putative involvement of nAChRs in several diseases. METHODS: We discuss the expression pattern of the subunits, the pharmacological tools for distinguishing them and their role in pathogenesis. RESULTS/ CONCLUSION: Long-standing efforts in this field should soon result in the finding of new molecules that might be applicable to situations ranging from neurological diseases to immune treatments.
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