OBJECTIVE: To assess physicians' concordance with Disease Activity Score in 28 joints (DAS28) categories calculated by an electronic medical record (EMR)-embedded disease activity calculator, as well as attitudes toward this application. METHODS: Fifteen rheumatologists used the EMR-embedded disease activity calculator to predict a rheumatoid arthritis (RA) DAS28 disease activity category at the time of each clinical encounter. RESULTS: Physician-predicted DAS28 disease activity categories ranged from high (>5.1, 15% of cohort, 66 of 429 patient visits) to moderate (>3.2-5.1, 21% of cohort, 90 of 429 patient visits) to low (2.6-3.2, 29% of cohort, 123 of 429 patient visits) to remission (<2.6, 35% of cohort, 150 of 429 patient visits). Overall concordance between calculated DAS28 results and physician-predicted RA disease activity was 64%. Using either the physician-predicted or the calculated DAS28 category as the gold standard, accuracy was greatest for patients in remission (75% and 88% accuracy, respectively) and those with high disease activity (68% and 79% accuracy, respectively), and less for patients with moderate (48% and 62% accuracy, respectively) or low disease activity (62% and 31% accuracy, respectively). CONCLUSION: Accurate physician prediction of DAS28 remission and high disease activity categories, even without immediate availability of the erythrocyte sedimentation rate or the C-reactive protein level at the time of the visit, may be used to guide quantitatively driven outpatient RA management.
OBJECTIVE: To assess physicians' concordance with Disease Activity Score in 28 joints (DAS28) categories calculated by an electronic medical record (EMR)-embedded disease activity calculator, as well as attitudes toward this application. METHODS: Fifteen rheumatologists used the EMR-embedded disease activity calculator to predict a rheumatoid arthritis (RA) DAS28 disease activity category at the time of each clinical encounter. RESULTS: Physician-predicted DAS28 disease activity categories ranged from high (>5.1, 15% of cohort, 66 of 429 patient visits) to moderate (>3.2-5.1, 21% of cohort, 90 of 429 patient visits) to low (2.6-3.2, 29% of cohort, 123 of 429 patient visits) to remission (<2.6, 35% of cohort, 150 of 429 patient visits). Overall concordance between calculated DAS28 results and physician-predicted RA disease activity was 64%. Using either the physician-predicted or the calculated DAS28 category as the gold standard, accuracy was greatest for patients in remission (75% and 88% accuracy, respectively) and those with high disease activity (68% and 79% accuracy, respectively), and less for patients with moderate (48% and 62% accuracy, respectively) or low disease activity (62% and 31% accuracy, respectively). CONCLUSION: Accurate physician prediction of DAS28 remission and high disease activity categories, even without immediate availability of the erythrocyte sedimentation rate or the C-reactive protein level at the time of the visit, may be used to guide quantitatively driven outpatientRA management.
Authors: Jing Cui; Saedis Saevarsdottir; Brian Thomson; Leonid Padyukov; Annette H M van der Helm-van Mil; Joanne Nititham; Laura B Hughes; Niek de Vries; Soumya Raychaudhuri; Lars Alfredsson; Johan Askling; Sara Wedrén; Bo Ding; Candace Guiducci; Gert Jan Wolbink; J Bart A Crusius; Irene E van der Horst-Bruinsma; Marieke Herenius; Michael E Weinblatt; Nancy A Shadick; Jane Worthington; Franak Batliwalla; Marlena Kern; Ann W Morgan; Anthony G Wilson; John D Isaacs; Kimme Hyrich; Michael F Seldin; Larry W Moreland; Timothy W Behrens; Cornelia F Allaart; Lindsey A Criswell; Tom W J Huizinga; Paul P Tak; S Louis Bridges; Rene E M Toes; Anne Barton; Lars Klareskog; Peter K Gregersen; Elizabeth W Karlson; Robert M Plenge Journal: Arthritis Rheum Date: 2010-07
Authors: Jeffrey A Sparks; Florencia Halperin; Jonathan C Karlson; Elizabeth W Karlson; Bonnie L Bermas Journal: Arthritis Care Res (Hoboken) Date: 2015-12 Impact factor: 4.794
Authors: Chen Lin; Elizabeth W Karlson; Helena Canhao; Timothy A Miller; Dmitriy Dligach; Pei Jun Chen; Raul Natanael Guzman Perez; Yuanyan Shen; Michael E Weinblatt; Nancy A Shadick; Robert M Plenge; Guergana K Savova Journal: PLoS One Date: 2013-08-16 Impact factor: 3.240