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Literature DB >> 19333131

Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels.

Abstract

Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase expressed abundantly in the heart. CaMKII targets numerous proteins involved in excitation-contraction coupling and excitability, and its activation may simultaneously contribute to heart failure and cardiac arrhythmias. In this review, we summarize the modulatory effects of CaMKII on cardiac ion channel function and expression and illustrate potential implications in the onset of arrhythmias via a computer model.

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Year: 2009 PMID： 19333131 PMCID： PMC2784004 DOI： 10.1097/FJC.0b013e3181a25078

Source DB: PubMed Journal: J Cardiovasc Pharmacol ISSN： 0160-2446 Impact factor: 3.105

73 in total

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Journal: Circ Res Date: 1993-10 Impact factor: 17.367

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Journal: Proc Natl Acad Sci U S A Date: 1994-09-27 Impact factor: 11.205

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Authors: M E Anderson; A P Braun; H Schulman; B A Premack
Journal: Circ Res Date: 1994-11 Impact factor: 17.367

9. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling.

Authors: Xu Wu; Tong Zhang; Julie Bossuyt; Xiaodong Li; Timothy A McKinsey; John R Dedman; Eric N Olson; Ju Chen; Joan Heller Brown; Donald M Bers
Journal: J Clin Invest Date: 2006-03 Impact factor: 14.808

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Journal: Circ Res Date: 1994-01 Impact factor: 17.367

79 in total

Review 1. CaMKII in myocardial hypertrophy and heart failure.

Authors: Mark E Anderson; Joan Heller Brown; Donald M Bers
Journal: J Mol Cell Cardiol Date: 2011-01-27 Impact factor: 5.000

2. S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ.

Authors: Jeffrey R Erickson; C Blake Nichols; Hitoshi Uchinoumi; Matthew L Stein; Julie Bossuyt; Donald M Bers
Journal: J Biol Chem Date: 2015-08-27 Impact factor: 5.157

3. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.

Authors: Ralph J van Oort; Mark D McCauley; Sayali S Dixit; Laetitia Pereira; Yi Yang; Jonathan L Respress; Qiongling Wang; Angela C De Almeida; Darlene G Skapura; Mark E Anderson; Donald M Bers; Xander H T Wehrens
Journal: Circulation Date: 2010-11-15 Impact factor: 29.690

4. Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations.

Authors: Balazs Horvath; Tamas Banyasz; Zhong Jian; Bence Hegyi; Kornel Kistamas; Peter P Nanasi; Leighton T Izu; Ye Chen-Izu
Journal: J Mol Cell Cardiol Date: 2013-09-06 Impact factor: 5.000

5. Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570.

Authors: Anne Blaich; Andrea Welling; Stefanie Fischer; Jörg Werner Wegener; Katharina Köstner; Franz Hofmann; Sven Moosmang
Journal: Proc Natl Acad Sci U S A Date: 2010-05-17 Impact factor: 11.205