K Douroudis1, E Prans, K Kisand, V Nemvalts, R Uibo. 1. Immunology Group, Institute of General and Molecular Pathology, University of Tartu, Ravila Str 19, Tartu 51014, Estonia.
Abstract
BACKGROUND: Cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule is an important regulator of T cell activation involved in the down-regulation of immune response. Polymorphisms within the CTLA-4 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. METHODS: In order to evaluate the impact of allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the CT60 A/G SNP and the CTBC217_1 C/T SNP were studied in a population of Estonian origin, including 61 LADA patients and 230 controls. RESULTS: It was found that the CT60 GG genotype (p=0.004) and the CTBC217_1 TT genotype (p=0.007) were significant associated with LADA. CONCLUSIONS: Our investigation revealed that not only type 1 diabetes but also LADA is associated with CTLA-4 gene polymorphisms. The role of CTLA-4 gene in the pathogenesis of LADA is open and needs further investigations.
BACKGROUND:Cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule is an important regulator of T cell activation involved in the down-regulation of immune response. Polymorphisms within the CTLA-4 gene have been suggested to confer susceptibility to autoimmune endocrine disorders. METHODS: In order to evaluate the impact of allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the CT60 A/G SNP and the CTBC217_1 C/T SNP were studied in a population of Estonian origin, including 61 LADA patients and 230 controls. RESULTS: It was found that the CT60 GG genotype (p=0.004) and the CTBC217_1 TT genotype (p=0.007) were significant associated with LADA. CONCLUSIONS: Our investigation revealed that not only type 1 diabetes but also LADA is associated with CTLA-4 gene polymorphisms. The role of CTLA-4 gene in the pathogenesis of LADA is open and needs further investigations.
Authors: Mohammad Khoshroo; Mohammad Ebrahim Khamseh; Ali Akbar Amir Zargar; Mojtaba Malek; Reza Falak; Mehdi Shekarabi Journal: Med J Islam Repub Iran Date: 2017-12-12
Authors: Margaret A McBride; Tazeen K Patil; Julia K Bohannon; Antonio Hernandez; Edward R Sherwood; Naeem K Patil Journal: Front Immunol Date: 2021-02-03 Impact factor: 7.561