Literature DB >> 19331592

Structural identifiability and indistinguishability of compartmental models.

James W T Yates1, R D Owen Jones, Mike Walker, S Y Amy Cheung.   

Abstract

The deterministic identifiability of models is only normally considered if a problem becomes apparent in the parameter identification stage of data analysis. If no problem is perceived then the analysis will continue. However, although the problem does not become apparent, the implications of ambiguities in what is inferred from the data should be considered. This paper reviews some fundamentals with respect to model indistinguishability and parameter identifiability.

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Year:  2009        PMID: 19331592     DOI: 10.1517/17425250902773426

Source DB:  PubMed          Journal:  Expert Opin Drug Metab Toxicol        ISSN: 1742-5255            Impact factor:   4.481


  9 in total

1.  Structural identifiability and sensitivity.

Authors:  Athanassios Iliadis
Journal:  J Pharmacokinet Pharmacodyn       Date:  2019-03-20       Impact factor: 2.745

2.  Deterministic identifiability of population pharmacokinetic and pharmacokinetic-pharmacodynamic models.

Authors:  Vijay K Siripuram; Daniel F B Wright; Murray L Barclay; Stephen B Duffull
Journal:  J Pharmacokinet Pharmacodyn       Date:  2017-06-13       Impact factor: 2.745

3.  Population Pharmacokinetics of the BTK Inhibitor Acalabrutinib and its Active Metabolite in Healthy Volunteers and Patients with B-Cell Malignancies.

Authors:  Helena Edlund; Sun Ku Lee; Marilee A Andrew; J Greg Slatter; Sergey Aksenov; Nidal Al-Huniti
Journal:  Clin Pharmacokinet       Date:  2019-05       Impact factor: 6.447

4.  Simultaneous pharmacokinetic model for rolofylline and both M1-trans and M1-cis metabolites.

Authors:  Mark Stroh; Matthew M Hutmacher; Jianmei Pang; Ryan Lutz; Hiroshi Magara; Julie Stone
Journal:  AAPS J       Date:  2013-01-25       Impact factor: 4.009

5.  Good Practices in Model-Informed Drug Discovery and Development: Practice, Application, and Documentation.

Authors:  S F Marshall; R Burghaus; V Cosson; S Y A Cheung; M Chenel; O DellaPasqua; N Frey; B Hamrén; L Harnisch; F Ivanow; T Kerbusch; J Lippert; P A Milligan; S Rohou; A Staab; J L Steimer; C Tornøe; S A G Visser
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2016-03-14

6.  What do we mean by identifiability in mixed effects models?

Authors:  Marc Lavielle; Leon Aarons
Journal:  J Pharmacokinet Pharmacodyn       Date:  2015-12-10       Impact factor: 2.745

7.  An approach for identifiability of population pharmacokinetic-pharmacodynamic models.

Authors:  V Shivva; J Korell; I G Tucker; S B Duffull
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2013-06-19

8.  Inference of complex biological networks: distinguishability issues and optimization-based solutions.

Authors:  Gábor Szederkényi; Julio R Banga; Antonio A Alonso
Journal:  BMC Syst Biol       Date:  2011-10-28

9.  Lost in modelling and simulation?

Authors:  Kiyohiko Sugano
Journal:  ADMET DMPK       Date:  2021-03-22
  9 in total

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