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Literature DB >> 19331349

BODIPY-based fluorescent probe for peroxynitrite detection and imaging in living cells.

Zhen-Ning Sun¹, Hua-Li Wang, Feng-Qin Liu, Yan Chen, Paul Kwong Hang Tam, Dan Yang.

Abstract

A fluorescent probe, HKGreen-2, has been developed based on a specific reaction between ketone and peroxynitrite (ONOO(-)). This probe is highly sensitive and selective for the detection of peroxynitrite not only in abiotic but also in biological systems. With this probe, we successfully detected peroxynitrite generated in murine macrophage cells activated by phorbol 12-myristate 13-acetate (PMA), interferon-gamma (IFN-gamma), and lipopolysaccharide (LPS). This new probe will be a useful tool for studying the roles of peroxynitrite in biological processes.

Entities: Chemical Gene Species

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Year: 2009 PMID： 19331349 DOI： 10.1021/ol900279z

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

30 in total

Review 10. Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury.

Authors: Xing-miao Chen; Han-sen Chen; Ming-jing Xu; Jian-gang Shen
Journal: Acta Pharmacol Sin Date: 2012-07-30 Impact factor: 6.150

BODIPY-based fluorescent probe for peroxynitrite detection and imaging in living cells.

1. Role of peroxynitrite in programmed cell death induced in self-incompatible pollen.

2. Reactive nitrogen species reactivities with nitrones: theoretical and experimental studies.

Review 3. State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research.

Review 4. Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery.

5. Readily accessible fluorescent probes for sensitive biological imaging of hydrogen peroxide.

6. Reduced fluoresceinamine for peroxynitrite quantification in the presence of nitric oxide.

7. A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells.

8. Synthesis and spectroscopic properties of β,β'-dibenzo-3,5,8-triaryl-BODIPYs.

9. Separation and detection of peroxynitrite using microchip electrophoresis with amperometric detection.

Review 10. Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury.