BACKGROUND: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. PATIENTS AND METHODS: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assessed in all. Gastritis scores were also assessed according to the updated Sydney system. RESULTS: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR = 4.05, 95% CI = 1.08-15.15, p = 0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98 +/- 0.87 vs. 1.55 +/- 0.96, p = 0.026). CONCLUSION: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.
BACKGROUND: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. PATIENTS AND METHODS: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assessed in all. Gastritis scores were also assessed according to the updated Sydney system. RESULTS: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR = 4.05, 95% CI = 1.08-15.15, p = 0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98 +/- 0.87 vs. 1.55 +/- 0.96, p = 0.026). CONCLUSION: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.
Authors: Cristina Angelescu; Florin Burada; Mihai Ioana; Radu Angelescu; Emil Moraru; Anca Riza; Sanda Marchian; Francisc Mixich; Mihai Cruce; Adrian Săftoiu Journal: Clin Transl Oncol Date: 2012-08-08 Impact factor: 3.405
Authors: B Ortega-Contreras; A Armella; J Appel; D Mennickent; J Araya; M González; E Castro; A M Obregón; L Lamperti; J Gutiérrez; E Guzmán-Gutiérrez Journal: Front Physiol Date: 2022-04-04 Impact factor: 4.755