| Literature DB >> 19330658 |
Hyo Song Kim1, Kyung Hee Kim, Kyoung Ha Kim, Myung Hee Chang, Sang Hoon Ji, Do Hyoung Lim, Kihyun Kim, Seok Jin Kim, Younghyeh Ko, Chang-Seok Ki, Sook Jung Jo, Jae Won Lee, Won Seog Kim.
Abstract
We investigated the value of Epstein-Barr virus (EBV) DNA load in unfractionated whole blood for the diagnosis and prognosis of EBV-associated lymphoma. From July 2004 to July 2007, we compared EBV DNA loads in 101 patients with lymphoma and 105 control individuals. The median copy number of EBV was higher in patients with EBV-positive lymphoma (p<0.001). In patients with natural killer (NK)/T-cell lymphomas, the median EBV DNA load at presentation was significantly related to the stage (p = 0.011) and response (p = 0.026). The newly proposed classification model for NK/T cell lymphoma showed EBV DNA load differed significantly between patients with upper and extra-upper aerodigestive tracts (p = 0.017). In 16 patients with NK/T-cell lymphoma monitored serially, EBV DNA load correlated well with the treatment response and clinical course. Further prospective studies are required to evaluate the diagnosing and monitoring role of whole blood EBV DNA for uniformly treated patients.Entities:
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Year: 2009 PMID： 19330658 DOI： 10.1080/10428190902803669
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022