[Insular modifications in glycerophosphate dehydrogenase in diabetes].

In the model of non-insulin-dependent diabetes found in adult rats injected with streptozotocin during the neonatal period, the activity of the mitochondrial glycerophosphate dehydrogenase is severely reduced in pancreatic islets. This coincides with a decreased contribution of aerobic to total glycolysis in intact islets and could account for the preferential impairment of the insulin secretory response to glucose.