Literature DB >> 19330454

Mediation and mechanism.

Tyler J VanderWeele1.   

Abstract

The concepts of mediation and mechanism are contrasted and logical implications holding between theses two concepts are described. The concept of mediation can be formalized using counterfactual definitions of indirect effects; the concept of mechanism can be formalized within the sufficient cause framework. It is shown that both concepts can be illustrated using a single causal diagram. It is also shown that mediation implies mechanism but mechanism need not imply mediation. Discussion is given regarding how the distinction between "statistical causality" and "mechanistic causality" is blurred by recent work in causal inference concerning methods for testing for mediation and mechanism.

Mesh:

Year:  2009        PMID: 19330454     DOI: 10.1007/s10654-009-9331-1

Source DB:  PubMed          Journal:  Eur J Epidemiol        ISSN: 0393-2990            Impact factor:   8.082


  15 in total

1.  Principal stratification in causal inference.

Authors:  Constantine E Frangakis; Donald B Rubin
Journal:  Biometrics       Date:  2002-03       Impact factor: 2.571

Review 2.  An overview of relations among causal modelling methods.

Authors:  Sander Greenland; Babette Brumback
Journal:  Int J Epidemiol       Date:  2002-10       Impact factor: 7.196

3.  Estimating the proportion of disease due to classes of sufficient causes.

Authors:  Kurt Hoffmann; Christin Heidemann; Cornelia Weikert; Matthias B Schulze; Heiner Boeing
Journal:  Am J Epidemiol       Date:  2005-11-17       Impact factor: 4.897

4.  Identifiability and exchangeability for direct and indirect effects.

Authors:  J M Robins; S Greenland
Journal:  Epidemiology       Date:  1992-03       Impact factor: 4.822

5.  Sufficient cause interactions and statistical interactions.

Authors:  Tyler J VanderWeele
Journal:  Epidemiology       Date:  2009-01       Impact factor: 4.822

6.  Marginal structural models for the estimation of direct and indirect effects.

Authors:  Tyler J VanderWeele
Journal:  Epidemiology       Date:  2009-01       Impact factor: 4.822

7.  A sufficient cause based approach to the assessment of mediation.

Authors:  Danella M Hafeman
Journal:  Eur J Epidemiol       Date:  2008-09-17       Impact factor: 8.082

8.  Causes.

Authors:  K J Rothman
Journal:  Am J Epidemiol       Date:  1976-12       Impact factor: 4.897

Review 9.  Conceptual problems in the definition and interpretation of attributable fractions.

Authors:  S Greenland; J M Robins
Journal:  Am J Epidemiol       Date:  1988-12       Impact factor: 4.897

10.  A further critique of the analytic strategy of adjusting for covariates to identify biologic mediation.

Authors:  Jay S Kaufman; Richard F Maclehose; Sol Kaufman
Journal:  Epidemiol Perspect Innov       Date:  2004-10-08
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  40 in total

1.  The Shanghai Changfeng Study: a community-based prospective cohort study of chronic diseases among middle-aged and elderly: objectives and design.

Authors:  Xin Gao; Albert Hofman; Yu Hu; Huandong Lin; Chouwen Zhu; Johannes Jeekel; Xuejuan Jin; Jiyao Wang; Jian Gao; Yiqing Yin; Naiqing Zhao
Journal:  Eur J Epidemiol       Date:  2010-12-01       Impact factor: 8.082

2.  Bias formulas for sensitivity analysis for direct and indirect effects.

Authors:  Tyler J VanderWeele
Journal:  Epidemiology       Date:  2010-07       Impact factor: 4.822

3.  Subtleties of explanatory language: what is meant by "mediation"?

Authors:  Tyler J Vanderweele
Journal:  Eur J Epidemiol       Date:  2011-05-08       Impact factor: 8.082

Review 4.  Identification of operating mediation and mechanism in the sufficient-component cause framework.

Authors:  Etsuji Suzuki; Eiji Yamamoto; Toshihide Tsuda
Journal:  Eur J Epidemiol       Date:  2011-03-30       Impact factor: 8.082

5.  Direct and indirect effects for neighborhood-based clustered and longitudinal data.

Authors:  T J VanderWeele
Journal:  Sociol Methods Res       Date:  2010-05-01

6.  The current deconstruction of paradoxes: one sign of the ongoing methodological "revolution".

Authors:  Miquel Porta; Paolo Vineis; Francisco Bolúmar
Journal:  Eur J Epidemiol       Date:  2015-07-12       Impact factor: 8.082

7.  Invited Commentary: The Continuing Need for the Sufficient Cause Model Today.

Authors:  Tyler J VanderWeele
Journal:  Am J Epidemiol       Date:  2017-06-01       Impact factor: 4.897

8.  Endogenous Selection Bias: The Problem of Conditioning on a Collider Variable.

Authors:  Felix Elwert; Christopher Winship
Journal:  Annu Rev Sociol       Date:  2014-06-02

9.  Sufficient Cause Representation of the Four-way Decomposition for Mediation and Interaction.

Authors:  Tyler J VanderWeele; Ian Shrier
Journal:  Epidemiology       Date:  2016-09       Impact factor: 4.822

10.  A test of biological and behavioral explanations for gender differences in telomere length: the multi-ethnic study of atherosclerosis.

Authors:  Belinda L Needham; Ana V Diez Roux; Chloe E Bird; Ryan Bradley; Annette L Fitzpatrick; David R Jacobs; Pamela Ouyang; Teresa E Seeman; Rebecca C Thurston; Dhananjay Vaidya; Steven Wang
Journal:  Biodemography Soc Biol       Date:  2014
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