Literature DB >> 19330369

Botulinum toxin injection in long-standing facial paralysis patients: improvement of facial symmetry observed up to 6 months.

Alessandra Grassi Salles1, Paula Nunes Toledo, Marcus Castro Ferreira.   

Abstract

BACKGROUND: Despite modern reanimation surgical techniques, facial paralysis presents with functional and aesthetic deficits. We evaluated facial symmetry after treating with botulinum toxin the healthy side of the face of 25 patients with long-standing facial paralysis who had previously been treated by surgical methods, with 6 months follow-up.
METHODS: Evaluation consisted of a clinical score, the two subscales of the Facial Disability Index, and surface electromyography. The mean botulinum toxin dose was 38 +/- 5 U (range = 15-69 U).
RESULTS: The clinical score showed significant reduction of asymmetry of 48.4% at 1 month and 16.8% after 6 months. The initial result was a consequence of reduced motion on the treated side combined with better motion on the paralyzed side. At 6 months, the treated side returned to basal scores. The residual effect seen in symmetry was due to an increase (18%) of motion in the paralyzed side. There was a significant decrease in the action potential of muscles on the nonparalyzed side 1 month post injection but completely reverted after 6 months. The Physical Function Index increased, but not significantly. The Social/Well-Being Function Index showed a significant increase at 6 months compared to pretreatment.
CONCLUSION: The proposed treatment improved facial symmetry for up to 6 months. Even after the end of the clinical effect of the drug, the paralyzed side's clinical score was 18% higher than pretreatment, with an increased quality of life.

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Year:  2009        PMID: 19330369     DOI: 10.1007/s00266-009-9337-9

Source DB:  PubMed          Journal:  Aesthetic Plast Surg        ISSN: 0364-216X            Impact factor:   2.326


  7 in total

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2.  Botulinum toxin to improve lower facial symmetry in facial nerve palsy.

Authors:  S A Sadiq; S Khwaja; S R Saeed
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3.  Modern concepts in facial nerve reconstruction.

Authors:  Gerd F Volk; Mira Pantel; Orlando Guntinas-Lichius
Journal:  Head Face Med       Date:  2010-11-01       Impact factor: 2.151

4.  Evaluation of oral-motor movements and facial mimic in patients with head and neck burns by a public service in Brazil.

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Journal:  Clinics (Sao Paulo)       Date:  2015-05-01       Impact factor: 2.365

5.  Dynamic smile reanimation in facial nerve palsy.

Authors:  Krishnakumar Krishnan Santha; Subin Joseph; Sameer Latheef; Saju Narayanan; Santhy Mohanachandran Nair; Bibilash Babu; Anand Sivadasan; Srivatsa Manjunath Shet; Rajesh Vardhan Pydi; Ajit Pati; Srikant Aruna Samantaray
Journal:  J Korean Assoc Oral Maxillofac Surg       Date:  2020-04-30

6.  Botulinum Toxin Therapy versus Anterior Belly of Digastric Transfer in the Management of Marginal Mandibular Branch of the Facial Nerve Palsy: A Patient Satisfaction Survey.

Authors:  Daniel P Butler; Jo I Leckenby; Ben H Miranda; Adriaan O Grobbelaar
Journal:  Arch Plast Surg       Date:  2015-11-16

7.  Mandibular range of motion in patients with idiopathic peripheral facial palsy.

Authors:  Fernanda Chiarion Sassi; Laura Davison Mangilli; Michele Conceição Poluca; Ricardo Ferreira Bento; Claudia Regina Furquim de Andrade
Journal:  Braz J Otorhinolaryngol       Date:  2011 Mar-Apr
  7 in total

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