Simon Podnar1. 1. Institute of Clinical Neurophysiology, Division of Neurology, University Medical Center Ljubljana, SI-1525 Ljubljana, Slovenia. simon.podnar@kclj.si
Abstract
OBJECTIVE: In interpretation of diagnostic findings the probability that an abnormal test accurately indicates pathology (i.e., the positive predictive value), and a normal test accurately excludes pathology (i.e., the negative predictive value) is the most important. For motor unit potential (MUP) analysis no such data has been published; hence this was the aim of this study. METHODS: In 31 patients with facioscapulohumeral muscular dystrophy (FSHD) and 34 controls the biceps brachii and vastus lateralis muscles were examined by concentric needle electromyography (EMG), using template operated MUP analysis. These results were compared to non-parametric reference data obtained in another group of 34 (biceps brachii) and 46 (vastus lateralis) control subjects. RESULTS: For the biceps brachii muscles sensitivity was 59%, specificity 91%, the positive predictive value 85%, and negative predictive value 72% with at least two criteria (mean values or outliers for MUP thickness, amplitude and duration) below the reference intervals. In addition, all subjects with three abnormal EMG criteria were FSHD patients, and 90% of subjects with normal EMG were controls. CONCLUSIONS: Template operated MUP analysis demonstrated reasonable predictive value for diagnosis and exclusion of myopathy. SIGNIFICANCE: Quantitative MUP analysis seems to be useful for the preliminary diagnosis of FSHD in patients with appropriate clinical picture.
OBJECTIVE: In interpretation of diagnostic findings the probability that an abnormal test accurately indicates pathology (i.e., the positive predictive value), and a normal test accurately excludes pathology (i.e., the negative predictive value) is the most important. For motor unit potential (MUP) analysis no such data has been published; hence this was the aim of this study. METHODS: In 31 patients with facioscapulohumeral muscular dystrophy (FSHD) and 34 controls the biceps brachii and vastus lateralis muscles were examined by concentric needle electromyography (EMG), using template operated MUP analysis. These results were compared to non-parametric reference data obtained in another group of 34 (biceps brachii) and 46 (vastus lateralis) control subjects. RESULTS: For the biceps brachii muscles sensitivity was 59%, specificity 91%, the positive predictive value 85%, and negative predictive value 72% with at least two criteria (mean values or outliers for MUP thickness, amplitude and duration) below the reference intervals. In addition, all subjects with three abnormal EMG criteria were FSHDpatients, and 90% of subjects with normal EMG were controls. CONCLUSIONS: Template operated MUP analysis demonstrated reasonable predictive value for diagnosis and exclusion of myopathy. SIGNIFICANCE: Quantitative MUP analysis seems to be useful for the preliminary diagnosis of FSHD in patients with appropriate clinical picture.