Literature DB >> 19329313

3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.

An T Vu1, Stephen T Cohn, Eugene A Terefenko, William J Moore, Puwen Zhang, Paige E Mahaney, Eugene J Trybulski, Igor Goljer, Rebecca Dooley, Jenifer A Bray, Grace H Johnston, Jennifer Leiter, Darlene C Deecher.   

Abstract

A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter.

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Year:  2009        PMID: 19329313     DOI: 10.1016/j.bmcl.2009.03.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Tungsten-catalyzed regio- and enantioselective aminolysis of trans-2,3-epoxy alcohols: an entry to virtually enantiopure amino alcohols.

Authors:  Chuan Wang; Hisashi Yamamoto
Journal:  Angew Chem Int Ed Engl       Date:  2014-10-19       Impact factor: 15.336

2.  Gadolinium-Catalyzed Regio- and Enantioselective Aminolysis of Aromatic trans-2,3-Epoxy Sulfonamides.

Authors:  Chuan Wang; Hisashi Yamamoto
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-08       Impact factor: 15.336

  2 in total

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