Literature DB >> 19329312

Conjugation with alpha-linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin.

Meng-Lei Huan1, Si-Yuan Zhou, Zeng-Hui Teng, Bang-le Zhang, Xin-You Liu, Jie-Pin Wang, Qi-Bing Mei.   

Abstract

The synthetic DOX-LNA conjugate was characterized by proton nuclear magnetic resonance and mass spectrometry. In addition, the purity of the conjugate was analyzed by reverse-phase high-performance liquid chromatography. The cellular uptake, intracellular distribution, and cytotoxicity of DOX-LNA were assessed by flow cytometry, fluorescence microscopy, liquid chromatography/electrospray ionization tandem mass spectrometry, and the tetrazolium dye assay using the in vitro cell models. The DOX-LNA conjugate showed substantially higher tumor-specific cytotoxicity compared with DOX.

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Year:  2009        PMID： 19329312     DOI： 10.1016/j.bmcl.2009.03.016

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  QbD-based development of α-linolenic acid potentiated nanoemulsion for targeted delivery of doxorubicin in DMBA-induced mammary gland carcinoma: in vitro and in vivo evaluation.

Authors:  Chandra Bhushan Tripathi; Poonam Parashar; Malti Arya; Mahendra Singh; Jovita Kanoujia; Gaurav Kaithwas; Shubhini A Saraf
Journal:  Drug Deliv Transl Res       Date:  2018-10       Impact factor: 4.617

2.  In vitro and in vivo antitumor activity of a novel pH-activated polymeric drug delivery system for doxorubicin.

Authors:  Menglei Huan; Bangle Zhang; Zenghui Teng; Han Cui; Jieping Wang; Xinyou Liu; Hui Xia; Siyuan Zhou; Qibing Mei
Journal:  PLoS One       Date:  2012-09-24       Impact factor: 3.240

3.  Deposition of doxorubicin in rats following administration of three newly synthesized doxorubicin conjugates.

Authors:  Menglei Huan; Shuang Tian; Han Cui; Bangle Zhang; Dan Su; Jieping Wang; Kangchu Li; Weidong Cao
Journal:  Biomed Res Int       Date:  2013-12-05       Impact factor: 3.411

Review 4.  Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery.

Authors:  Lingling Huang; Jianmiao Yang; Tiantian Wang; Jianqing Gao; Donghang Xu
Journal:  J Nanobiotechnology       Date:  2022-01-24       Impact factor: 10.435

Review 5.  n-3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer.

Authors:  Cinzia Giordano; Pierluigi Plastina; Ines Barone; Stefania Catalano; Daniela Bonofiglio
Journal:  Int J Mol Sci       Date:  2020-03-26       Impact factor: 5.923
  5 in total

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