| Literature DB >> 19328792 |
Thomas Klonisch1, Aleksandra Glogowska, Ana A Gratao, Marjeta Grzech, Andreea Nistor, Mark Torchia, Ekkehard Weber, Martin Hrabé de Angelis, Birgit Rathkolb, Hoang-Vu Cuong, Eckhard Wolf, Marlon R Schneider.
Abstract
We generated transgenic mice to study the in vivo role of the cytoplasmic domain of human proEGF (proEGFcyt). Post-pubertal proEGFcyt transgenic (tg) mice displayed an up to 15% reduction in body weight, including smaller kidney and brain weights as compared to control littermates. Renal histology, gene expression profiles, and functional parameters were normal. In both sexes, serum levels of IGFBP-3 were reduced. Circulating IGF-I/IGF-II levels were unchanged. Histomorphological analysis revealed isolated foci of liver necrosis specific to proEGFcyt tg mice. In conclusion, we identified proEGF cytoplasmic domain as a novel modulator of whole body and organ-specific growth in mice.Entities:
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Year: 2009 PMID： 19328792 DOI： 10.1016/j.febslet.2009.03.051
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124