| Literature DB >> 19328683 |
Brijesh Kumar Srivastava1, Rina Soni, Jayendra Z Patel, Amit Joharapurkar, Nisha Sadhwani, Samadhan Kshirsagar, Bhupendra Mishra, Vijay Takale, Sunil Gupta, Purvi Pandya, Prashant Kapadnis, Manish Solanki, Harilal Patel, Prasenjit Mitra, Mukul R Jain, Pankaj R Patel.
Abstract
A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as potentially useful antiobesity agent. Structural requirements for selective CB1 receptor antagonistic activity of 5-thienyl pyrazole derivatives included the structural similarity with potent, specific antagonist rimonabant 1. Compound 3 has been identified as a hair growth stimulator and an antiobesity agent in animal models.Entities:
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Year: 2009 PMID： 19328683 DOI： 10.1016/j.bmcl.2009.03.046
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823