| Literature DB >> 19327884 |
Julie Mou Larsen1, Ib Jarle Christensen, Hans Jørgen Nielsen, Ulla Hansen, Bolette Bjerregaard, Jan Fredrik Talts, Lars-Inge Larsson.
Abstract
The endogenous retroviral envelope protein syncytin is involved in cell fusions and has also been associated with immunomodulatory functions. Syncytin is currently known to be expressed in the placenta, testis and brain as well as in breast and endometrial carcinomas. Using a newly developed monoclonal syncytin antibody we have assessed syncytin expression in a retrospective series of 140 colorectal cancer patients. Variable degrees of syncytin expression were detected in both colonic and rectal tumors and the prognostic impact of such expression was analysed with the Kaplan-Meier method and the Cox proportional hazard model. Interestingly, increased syncytin expression was associated with decreased overall survival in rectal but not in colonic cancer patients. Thus, the prognostic impact of syncytin expression appears to vary with the tumor type.Entities:
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Year: 2009 PMID： 19327884 DOI： 10.1016/j.canlet.2009.02.008
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679