| Literature DB >> 19322630 |
Marija Denčić-Fekete1, Vesna Đorđević2, Clelia Tiziana Storlazzi3, Gradimir Janković2, Andrija Bogdanović2, Jelica Jovanović2, Mariano Rocchi3, Biljana Todorić-Živanović4, Milica Strnad4, Mirjana Gotić2.
Abstract
A patient with t(9;22)-positive chronic myelogenous leukemia (CML) developed a resistance to therapy with imatinib mesylate (Glivec) which coincided with the appearance of t(5;6;12) in the same cells with t(9;22) [46,XX,t(5;6;12)(q14?;q21?;q23?),t(9;22)(q34;q11)]. She remains in a continuous chronic phase of CML. This is the first reported instance of karyotype evolution temporally associated, and possibly involved, with the induction of resistance to imatinib mesylate but without any signs of evolution of leukemia toward a more anaplastic and aggressive form.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19322630 DOI： 10.1007/s12185-009-0275-8
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490