| Literature DB >> 19322440 |
Mi-Hyun Kim1, Sea-Hoon Choi, Yeon-Ju Lee, Jihye Lee, Keepyung Nahm, Byeong-Seon Jeong, Hyeung-Geun Park, Sang-Sup Jew.
Abstract
The phase-transfer catalytic alkylation of N,N-dialkylmalonamic tert-butyl esters in the presence of 1 mol% of (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-alpha-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss of chirality.Entities:
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Year: 2009 PMID： 19322440 DOI： 10.1039/b821468a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222