| Literature DB >> 19322214 |
Antonella Di Cesare1, Paola Di Meglio, Frank O Nestle.
Abstract
Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis.Entities:
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Year: 2009 PMID： 19322214 DOI： 10.1038/jid.2009.59
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551