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Literature DB >> 1932212

New hydrazone derivatives of adriamycin and their immunoconjugates--a correlation between acid stability and cytotoxicity.

T Kaneko¹, D Willner, I Monkovíc, J O Knipe, G R Braslawsky, R S Greenfield, D M Vyas.

Abstract

New N-substituted hydrazine linkers were synthesized and their hydrazone derivatives of adriamycin were prepared. These functionalized adriamycin derivatives were conjugated with a monoclonal antibody, 5E9. The release rate of adriamycin from the hydrazones and from some of the conjugates was studied, and their relationship to the IC50's of the conjugate against 5E9-positive Daudi cells was investigated.

Entities: Chemical Disease Species

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Year: 1991 PMID： 1932212 DOI： 10.1021/bc00009a001

Source DB: PubMed Journal: Bioconjug Chem ISSN： 1043-1802 Impact factor: 4.774

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Cited

31 in total

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Authors: D Scott Wilbur; Ming-Kuan Chyan; Donald K Hamlin; Holly Nguyen; Robert L Vessella
Journal: Bioconjug Chem Date: 2011-05-05 Impact factor: 4.774

2. Development of multifunctional hyaluronan-coated nanoparticles for imaging and drug delivery to cancer cells.

Authors: Mohammad H El-Dakdouki; David C Zhu; Kheireddine El-Boubbou; Medha Kamat; Jianjun Chen; Wei Li; Xuefei Huang
Journal: Biomacromolecules Date: 2012-03-13 Impact factor: 6.988

3. Epirubicin-[Anti-HER2/neu] Synthesized with an Epirubicin-(C₁₃-imino)-EMCS Analog: Anti-Neoplastic Activity against Chemotherapeutic-Resistant SKBr-3 Mammary Carcinoma in Combination with Organic Selenium.

Authors: Cody P Coyne; Toni Jones; Andrzej Sygula; John Bailey; Lesya Pinchuk
Journal: J Cancer Ther Date: 2011-03

4. A Computational/Experimental Assessment of Antitumor Activity of Polymer Nanoassemblies for pH-Controlled Drug Delivery to Primary and Metastatic Tumors.

Authors: Louis T Curtis; Piotr Rychahou; Younsoo Bae; Hermann B Frieboes
Journal: Pharm Res Date: 2016-06-29 Impact factor: 4.200

New hydrazone derivatives of adriamycin and their immunoconjugates--a correlation between acid stability and cytotoxicity.

1. Reagents for astatination of biomolecules. 5. Evaluation of hydrazone linkers in (211)At- and (125)I-labeled closo-decaborate(2-) conjugates of Fab' as a means of decreasing kidney retention.

2. Development of multifunctional hyaluronan-coated nanoparticles for imaging and drug delivery to cancer cells.

3. Epirubicin-[Anti-HER2/neu] Synthesized with an Epirubicin-(C₁₃-imino)-EMCS Analog: Anti-Neoplastic Activity against Chemotherapeutic-Resistant SKBr-3 Mammary Carcinoma in Combination with Organic Selenium.

4. A Computational/Experimental Assessment of Antitumor Activity of Polymer Nanoassemblies for pH-Controlled Drug Delivery to Primary and Metastatic Tumors.

Review 5. Utilization of monoclonal antibody-targeted nanomaterials in the treatment of cancer.

Review 6. Antibody Drug Conjugates: Preclinical Considerations.

7. Is the drug-responsive NADH oxidase of the cancer cell plasma membrane a molecular target for adriamycin?

8. Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles.

9. A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas.

Review 10. Nature as a source of inspiration for cationic lipid synthesis.