BACKGROUND/AIM: To investigate the impact of vascular burden (assessed by the number of vascular risk factors and diseases) on the cognition of persons with amnestic mild cognitive impairment (aMCI). METHODS: This study included 145 participants; 68 meeting criteria for amnesic single-domain or multiple-domain MCI and 77 matched controls. Four cognitive domains were assessed: executive functions, processing speed, episodic memory and general cognitive functioning. RESULTS: A larger vascular burden among aMCI is correlated with lower performance in the executive domain. In addition, persons with aMCI with high vascular burden were more frequently of the multiple domain subtype, whereas persons with no vascular burden were more frequently of the single domain subtype. CONCLUSION: Our findings suggest that the combined effect of multiple vascular risk factors and diseases increases the amount of executive impairment in persons with aMCI. Vascular burden may play an important role in the heterogeneity of aMCI by impairing cognitive functions other than memory.
BACKGROUND/AIM: To investigate the impact of vascular burden (assessed by the number of vascular risk factors and diseases) on the cognition of persons with amnestic mild cognitive impairment (aMCI). METHODS: This study included 145 participants; 68 meeting criteria for amnesic single-domain or multiple-domain MCI and 77 matched controls. Four cognitive domains were assessed: executive functions, processing speed, episodic memory and general cognitive functioning. RESULTS: A larger vascular burden among aMCI is correlated with lower performance in the executive domain. In addition, persons with aMCI with high vascular burden were more frequently of the multiple domain subtype, whereas persons with no vascular burden were more frequently of the single domain subtype. CONCLUSION: Our findings suggest that the combined effect of multiple vascular risk factors and diseases increases the amount of executive impairment in persons with aMCI. Vascular burden may play an important role in the heterogeneity of aMCI by impairing cognitive functions other than memory.
Authors: Lynn Ossher; Ellen Bialystok; Fergus I M Craik; Kelly J Murphy; Angela K Troyer Journal: J Gerontol B Psychol Sci Soc Sci Date: 2012-03-27 Impact factor: 4.077
Authors: Alexa Pichet Binette; Julie Gonneaud; Jacob W Vogel; Renaud La Joie; Pedro Rosa-Neto; D Louis Collins; Judes Poirier; John C S Breitner; Sylvia Villeneuve; Etienne Vachon-Presseau Journal: Brain Date: 2020-02-01 Impact factor: 13.501
Authors: Cedric Annweiler; Olivier Beauchet; Robert Bartha; Vladimir Hachinski; Manuel Montero-Odasso Journal: PLoS One Date: 2014-01-31 Impact factor: 3.240