| Literature DB >> 1932183 |
G Paganelli1, M Stella, P De Nardi, P Magnani, F Zito, A G Siccardi, V Di Carlo, F Fazio.
Abstract
A major inconvenience of intraoperative tumor detection with radiolabeled monoclonal antibody (MoAb) by means of a probe is the long interval needed between the injection of MoAb and surgery (at least 20 days). We describe a new method which entails injection of 125I-labeled biotinylated monoclonal antibodies and cold avidin in order to obtain a rapid blood clearance of the radiotracer. The first clinical application of this protocol has been carried out in a colon cancer patient operated on six days after the administration of 125I-labeled biotinylated MoAb and cold avidin, with an optimal tumor-to-normal tissue ratio and with 90% of the circulating radioactivity cleared in two days.Entities:
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Year: 1991 PMID： 1932183
Source DB: PubMed Journal: J Nucl Biol Med ISSN： 0368-3249