| Literature DB >> 19321256 |
Yanhua Bai1, Kennichi Kakudo, Misa Nakamura, Takashi Ozaki, Yaqiong Li, Zhiyan Liu, Ichiro Mori, Akira Miyauchi, Gengyin Zhou.
Abstract
Loss of cellular polarity/cohesiveness and periostin expression are involved in the epithelial-mesenchymal transition in the epithelial malignancies. Their roles in papillary thyroid carcinoma were studied. There was a significant correlation between the loss of cellular polarity/cohesiveness in the invasive front and the up-regulation of periostin in tumors. Both of them were significantly correlated with extrathyroid invasion, pT and lymph node metastasis. Our results suggest that the loss of cellular polarity/cohesiveness is a useful parameter for predicting prognosis of patients with papillary thyroid carcinoma, and periostin could be a candidate gene for therapeutic targeting for the blockage of tumor invasion.Entities:
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Year: 2009 PMID： 19321256 DOI： 10.1016/j.canlet.2009.02.043
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679