| Literature DB >> 19321172 |
B Li1, A Van Schepdael, J Hoogmartens, E Adams.
Abstract
The characterization of unknown impurities present in tobramycin by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed-phase (RP)-LC method using a volatile mobile phase containing a perfluorinated ion-pair reagent was developed and coupled with an ion trap mass spectrometer. The structures of the unknown impurities were deduced by comparison of their fragmentation patterns with those of the available reference substances obtained by LC-MS(n) experiments.Entities:
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Year: 2009 PMID： 19321172 DOI： 10.1016/j.chroma.2009.03.023
Source DB: PubMed Journal: J Chromatogr A ISSN： 0021-9673 Impact factor: 4.759