Loren Lipworth1, Robert E Tarone, Joseph K McLaughlin. 1. Rockville, Md.; and Nashville, Tenn. From the International Epidemiology Institute, Vanderbilt University Medical Center, and Vanderbilt-Ingram Cancer Center.
Abstract
BACKGROUND: In the past, concerns about lymphoma among women with breast implants have been raised by anecdotal observations. A recent report of a case-control study from The Netherlands reported an association of breast implants with anaplastic large T-cell lymphoma, but limitations inherent in the study design and the restriction of the association to saline implants preclude any causal evaluation. METHODS: To determine whether lymphoma risk is in fact elevated in women with breast implants, the authors have reviewed the evidence from five long-term follow-up studies comprising over 43,000 women with cosmetic breast implants followed for up to 37 years, which reported results specifically regarding the incidence of non-Hodgkin's lymphoma, among other cancers. RESULTS: Overall, there were 48 observed incident cases of non-Hodgkin's lymphoma compared with 53.9 cases expected, yielding a summary standardized incidence ratio of 0.89 (95 percent confidence interval, 0.67 to 1.18). None of the epidemiologic cohort studies reported a primary lymphoma originating in the breast. CONCLUSIONS: To date, there is no credible evidence of an increase of non-Hodgkin's lymphoma regardless of site or specifically originating in the breast among women with cosmetic breast implants.
BACKGROUND: In the past, concerns about lymphoma among women with breast implants have been raised by anecdotal observations. A recent report of a case-control study from The Netherlands reported an association of breast implants with anaplastic large T-cell lymphoma, but limitations inherent in the study design and the restriction of the association to saline implants preclude any causal evaluation. METHODS: To determine whether lymphoma risk is in fact elevated in women with breast implants, the authors have reviewed the evidence from five long-term follow-up studies comprising over 43,000 women with cosmetic breast implants followed for up to 37 years, which reported results specifically regarding the incidence of non-Hodgkin's lymphoma, among other cancers. RESULTS: Overall, there were 48 observed incident cases of non-Hodgkin's lymphoma compared with 53.9 cases expected, yielding a summary standardized incidence ratio of 0.89 (95 percent confidence interval, 0.67 to 1.18). None of the epidemiologic cohort studies reported a primary lymphoma originating in the breast. CONCLUSIONS: To date, there is no credible evidence of an increase of non-Hodgkin's lymphoma regardless of site or specifically originating in the breast among women with cosmetic breast implants.
Authors: Melissa G Lechner; Stephen Lade; Daniel J Liebertz; H Miles Prince; Garry S Brody; Howard R Webster; Alan L Epstein Journal: Cancer Date: 2010-11-08 Impact factor: 6.860
Authors: Sophia S Wang; Dennis Deapen; Jenna Voutsinas; James V Lacey; Yani Lu; Huiyan Ma; Christina A Clarke; Dennis Weisenburger; Stephen J Forman; Leslie Bernstein Journal: Br J Haematol Date: 2015-10-12 Impact factor: 6.998