Thyroid hormone: half-sites and insights. Molecular Approaches to the Study of Thyroid hormone Action: a Keystone Symposium, Tamarron, CO, USA, March 8-14, 1991.

As is evident from the range of topics addressed in this review, T3 has important and interesting effects on virtually every biological system in higher organisms. Many of these effects are beginning to be understood at the molecular level, while others are not far behind. It is striking that the diversity of biological activities of T3 is reflected in a broad spectrum of molecular mechanisms. Even within the relatively circumscribed paradigm of receptor activation by hormone binding, a surprisingly large number of possible interactions and complications has been discovered. This richness of alternative interactions leads directly to complex and unanticipated regulatory possibilities. A major strength of this meeting was that it encompassed the broad range of T3 effects and thereby was able to provide something new for every attendee. From this perspective, it is easy to predict that study of T3 will continue to provide new and surprising insights into major biological questions for years to come.