| Literature DB >> 19318248 |
Joanne L Thomson1, Wesley P Blackaby, Andrew S R Jennings, Simon C Goodacre, Andrew Pike, Steve Thomas, Terry A Brown, Alison Smith, Gopalan Pillai, Leslie J Street, Richard T Lewis.
Abstract
A series of heterocyclic sulfonamides have been developed which are potent and selective inhibitors of hGlyT1. SAR studies to optimise the in vitro and in vivo properties are described. Optimisation of the central scaffold resulted in cyclohexane sulfones 28 and 29, which have good PK properties and show promise for further development.Entities:
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Year: 2009 PMID： 19318248 DOI： 10.1016/j.bmcl.2009.02.102
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823