PURPOSE: The purpose of this study was to compare the effectiveness of fast and slow biodegradation of basic fibroblast growth factor (bFGF)-gelatin hydrogel complex on bone regeneration around fenestrated implants as a new augmentation drug delivery system. METHODS: Nine titanium implants (3.3mm diameter and 10mm length) were placed into the edentulous areas of the mandibles of three adult beagle dogs with four screws exposed at the upper buccal side. The effectiveness of bFGF-gelatin hydrogel complexes of varying degradation types used to cover implant screws without membrane were compared with 1 microg and 10 microg bFGF-98 wt% gelatin as the fast degradation type and 10 microg bFGF-95 wt% gelatin as the slow degradation type. After 4 weeks, bone regeneration around the screws was evaluated histologically and histomorphometrically. RESULTS: With use of 10 microg bFGF, regenerated bone around exposed screws was clearly seen in both the fast and slow degradation type groups. In contrast, little bone formation was seen in the fast degradation-type group with 1 microg bFGF. Height of regenerated bone for the slow degradation-type complex group was significantly greater than for the fast degradation-type group with 1 microg bFGF (P<0.05). CONCLUSION: These results suggest that use of slow degradation-type bFGF-gelatin hydrogel complex may accelerate bone regeneration around fenestrated implants at an early stage of bone regeneration.
PURPOSE: The purpose of this study was to compare the effectiveness of fast and slow biodegradation of basic fibroblast growth factor (bFGF)-gelatin hydrogel complex on bone regeneration around fenestrated implants as a new augmentation drug delivery system. METHODS: Nine titanium implants (3.3mm diameter and 10mm length) were placed into the edentulous areas of the mandibles of three adult beagle dogs with four screws exposed at the upper buccal side. The effectiveness of bFGF-gelatin hydrogel complexes of varying degradation types used to cover implant screws without membrane were compared with 1 microg and 10 microg bFGF-98 wt% gelatin as the fast degradation type and 10 microg bFGF-95 wt% gelatin as the slow degradation type. After 4 weeks, bone regeneration around the screws was evaluated histologically and histomorphometrically. RESULTS: With use of 10 microg bFGF, regenerated bone around exposed screws was clearly seen in both the fast and slow degradation type groups. In contrast, little bone formation was seen in the fast degradation-type group with 1 microg bFGF. Height of regenerated bone for the slow degradation-type complex group was significantly greater than for the fast degradation-type group with 1 microg bFGF (P<0.05). CONCLUSION: These results suggest that use of slow degradation-type bFGF-gelatin hydrogel complex may accelerate bone regeneration around fenestrated implants at an early stage of bone regeneration.
Authors: Paulo Cezar Vidal Carneiro de Albuquerque; Saulo Monteiro Dos Santos; José Lamartine de Andrade Aguiar; Nicodemus Pontes Filho; Roberto José Vieira de Mello; Mariana Lúcia Correia Ramos Costa; Clarissa Miranda Carneiro de Albuquerque Olbertz; Tarciana Mendonça de Souza Almeida; Alessandro Henrique da Silva Santos; Joacil Carlos da Silva Journal: Rev Bras Ortop Date: 2015-12-06
Authors: Julia Scheinpflug; Moritz Pfeiffenberger; Alexandra Damerau; Franziska Schwarz; Martin Textor; Annemarie Lang; Frank Schulze Journal: Genes (Basel) Date: 2018-05-10 Impact factor: 4.096