Carcinoma arising in cyclosporin-induced gingival hyperplasia.

A patient with intra-oral squamous cell carcinoma arising in an area of cyclosporin-induced gingival hyperplasia associated with a renal transplant is presented. This appears to be the first reported case of its kind. Subsequently, the patient developed a carcinoma of the lateral margin of the tongue, with metastasis to the deep cervical lymph nodes. The incidence and types of malignancy following conventional immunosuppressive and cyclosporin therapy are briefly reviewed. Long-term frequent follow-up of cyclosporin-treated patients is recommended to facilitate early diagnosis of such lesions.