BACKGROUND: Yellow fever, a mosquito-borne viral haemorrhagic fever, is one of the most lethal viral diseases. At present, an efficient vaccine for prevention is available, but may cause serious adverse events. METHODS: The authors review the up-to-date knowledge for serious adverse events of the yellow fever vaccine (YFSAE): hypersensitivity reactions, neurotropic and viscerotropic syndromes. RESULTS: The incidence of YFSAE has been associated with increasing age and thymus disorders, but still a number of cases with any risk factor remain unexplained, which suggests that other factors, from the virus or the host, could be involved in the appearance of these postvaccinal adverse events. CONCLUSIONS: YFSAE are uncommon but must be prevented. Further research on the virus-host immune response is needed to have a better understanding of the basis for the appearance of these severe side effects after vaccination. Vaccination should be limited to people with a true risk of exposure to wild-type yellow fever virus.
BACKGROUND:Yellow fever, a mosquito-borne viral haemorrhagic fever, is one of the most lethal viral diseases. At present, an efficient vaccine for prevention is available, but may cause serious adverse events. METHODS: The authors review the up-to-date knowledge for serious adverse events of the yellow fever vaccine (YFSAE): hypersensitivity reactions, neurotropic and viscerotropic syndromes. RESULTS: The incidence of YFSAE has been associated with increasing age and thymus disorders, but still a number of cases with any risk factor remain unexplained, which suggests that other factors, from the virus or the host, could be involved in the appearance of these postvaccinal adverse events. CONCLUSIONS: YFSAE are uncommon but must be prevented. Further research on the virus-host immune response is needed to have a better understanding of the basis for the appearance of these severe side effects after vaccination. Vaccination should be limited to people with a true risk of exposure to wild-type yellow fever virus.
Authors: Justin G Julander; Ashok K Jha; Jung-Ae Choi; Kie-Hoon Jung; Donald F Smee; John D Morrey; Chung K Chu Journal: Antiviral Res Date: 2010-03-20 Impact factor: 5.970
Authors: Brett M Forshey; Carolina Guevara; V Alberto Laguna-Torres; Manuel Cespedes; Jorge Vargas; Alberto Gianella; Efrain Vallejo; César Madrid; Nicolas Aguayo; Eduardo Gotuzzo; Victor Suarez; Ana Maria Morales; Luis Beingolea; Nora Reyes; Juan Perez; Monica Negrete; Claudio Rocha; Amy C Morrison; Kevin L Russell; Patrick J Blair; James G Olson; Tadeusz J Kochel Journal: PLoS Negl Trop Dis Date: 2010-08-10
Authors: Ana Cristina Vanderley Oliveira; Licia Maria Henrique da Mota; Leopoldo Luiz Dos Santos-Neto; Jozélio Freire De Carvalho; Iramaya Rodrigues Caldas; Olindo Assis Martins Filho; Pedro Luis Tauil Journal: Autoimmune Dis Date: 2014-10-22