BACKGROUND: Cigarette smoke is strongly associated with NSCLC, but the carcinogenesis of NSCLC is poorly understood. METHODS: To discover the role of oxidative stress and anti-oxidative defense in NSCLC, we measured NADPH oxidase (NOX) activity, myeloperoxidase activity, 8-OHdG, and glutathione content from lung specimens. These came from 32 patients: 22 NSCLC patients and ten controls without cancer. RESULTS: In NSCLC patients, NOX activity was significantly higher both in the malignant (p = 0.001) and non-malignant (p = 0.044) samples from NSCLC patients, than in the control specimens. Myeloperoxidase activity was lower (p = 0.001) and glutathione content (p = 0.009) higher in malignant tissue. No significant difference was observable in 8-OHdG content between patient groups. CONCLUSIONS: Increase in NOX activity in the malignant tissues was independent of smoking history and myeloperoxidase activity, suggesting its independent role in NSCLC pathogenesis.
BACKGROUND: Cigarette smoke is strongly associated with NSCLC, but the carcinogenesis of NSCLC is poorly understood. METHODS: To discover the role of oxidative stress and anti-oxidative defense in NSCLC, we measured NADPH oxidase (NOX) activity, myeloperoxidase activity, 8-OHdG, and glutathione content from lung specimens. These came from 32 patients: 22 NSCLCpatients and ten controls without cancer. RESULTS: In NSCLCpatients, NOX activity was significantly higher both in the malignant (p = 0.001) and non-malignant (p = 0.044) samples from NSCLCpatients, than in the control specimens. Myeloperoxidase activity was lower (p = 0.001) and glutathione content (p = 0.009) higher in malignant tissue. No significant difference was observable in 8-OHdG content between patient groups. CONCLUSIONS: Increase in NOX activity in the malignant tissues was independent of smoking history and myeloperoxidase activity, suggesting its independent role in NSCLC pathogenesis.
Authors: Nadzeya V Marozkina; Christina Wei; Sean Yemen; Horst Wallrabe; Alykhan S Nagji; Lei Liu; Tatiana Morozkina; David R Jones; Benjamin Gaston Journal: Am J Respir Cell Mol Biol Date: 2012-01 Impact factor: 6.914
Authors: Leonardo Lisbôa da Motta; Carolina B Müller; Marco A De Bastiani; Guilherme A Behr; Fernanda S França; Ricardo F da Rocha; Juliane B Minotto; Rosalva T Meurer; Marilda C Fernandes; Adriana Roehe; Melissa M Markoski; Cristiano F Andrade; Mauro A A Castro; Fábio Klamt Journal: J Cancer Res Clin Oncol Date: 2014-01-22 Impact factor: 4.553
Authors: Fuminori Hyodo; Ryan M Davis; Emi Hyodo; Shingo Matsumoto; Murali C Krishna; James B Mitchell Journal: Int J Oncol Date: 2012-09-24 Impact factor: 5.650