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Literature DB >> 19308454

MIC6 associates with aldolase in host cell invasion by Toxoplasma gondii.

Bin Zheng¹, Ai He, Ming Gan, Zhouya Li, Hualiang He, Ximei Zhan.

Abstract

The transmembrane microneme protein MIC6 and its partner MIC1, MIC4 comprise an adhesive complex that play important roles in host cell attachment by the obligate intracellular parasite Toxoplasma gondii. Successful penetration of host cells by T. gondii depends on coordinated interactions between MICs complex and the parasite's cytoskeleton. We have identified that the carboxy-terminal cytoplasmic domain (C domain) of MIC6 interacts with aldolase and the parasite cytoskeleton. Our finding uncovers new features regarding MIC6-aldolase interactions in host cell invasion by T. gondii.

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Year: 2009 PMID： 19308454 DOI： 10.1007/s00436-009-1401-5

Source DB: PubMed Journal: Parasitol Res ISSN： 0932-0113 Impact factor: 2.289

26 in total

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Journal: J Exp Med Date: 2005-01-31 Impact factor: 14.307

8. Identification and characterization of an escorter for two secretory adhesins in Toxoplasma gondii.

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Journal: J Cell Biol Date: 2001-02-05 Impact factor: 10.539

9. Aldolase exists in both the fluid and solid phases of cytoplasm.

Authors: L Pagliaro; D L Taylor
Journal: J Cell Biol Date: 1988-09 Impact factor: 10.539

10. Identification of the membrane receptor of a class XIV myosin in Toxoplasma gondii.

Authors: Elizabeth Gaskins; Stacey Gilk; Nicolette DeVore; Tara Mann; Gary Ward; Con Beckers
Journal: J Cell Biol Date: 2004-05-03 Impact factor: 10.539

15 in total

1. Vaccination with a DNA vaccine coding for perforin-like protein 1 and MIC6 induces significant protective immunity against Toxoplasma gondii.

Authors: Hai-Kuo Yan; Zi-Guo Yuan; Hui-Qun Song; Eskild Petersen; Yang Zhou; Di Ren; Dong-Hui Zhou; Hao-Xin Li; Rui-Qing Lin; Gui-Lian Yang; Xing-Quan Zhu
Journal: Clin Vaccine Immunol Date: 2012-02-29

2. Toxoplasma aldolase is required for metabolism but dispensable for host-cell invasion.

Authors: Bang Shen; L David Sibley
Journal: Proc Natl Acad Sci U S A Date: 2014-02-18 Impact factor: 11.205

3. A transmembrane domain containing pellicle protein of Toxoplasma gondii enhances virulence and invasion after extracellular stress.

Authors: T Matthew Payne; Peder J Lund; Laura J Knoll
Journal: Mol Biochem Parasitol Date: 2011-06-02 Impact factor: 1.759

4. Toxoplasma gondii transmembrane microneme proteins and their modular design.

Authors: Lilach Sheiner; Joana M Santos; Natacha Klages; Fabiola Parussini; Noelle Jemmely; Nikolas Friedrich; Gary E Ward; Dominique Soldati-Favre
Journal: Mol Microbiol Date: 2010-06-09 Impact factor: 3.501

Review 5. Family members stick together: multi-protein complexes of malaria parasites.

Authors: Andrea Kuehn; Nina Simon; Gabriele Pradel
Journal: Med Microbiol Immunol Date: 2010-04-24 Impact factor: 3.402

6. A Role for Basigin in Toxoplasma gondii Infection.

Authors: Azadeh Nasuhidehnavi; Yanlin Zhao; Ankita Punetha; Andrew Hemphill; Hong Li; Tyler J Bechtel; Theresa Rager; Bingcong Xiong; Vasileios I Petrou; Marc-Jan Gubbels; Eranthie Weerapana; George S Yap
Journal: Infect Immun Date: 2022-08-01 Impact factor: 3.609

10. Immunization With a DNA Vaccine Cocktail Encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 Genes Protects Mice Against Chronic Toxoplasmosis.

Authors: Nian-Zhang Zhang; Qi Gao; Meng Wang; Hany M Elsheikha; Bo Wang; Jin-Lei Wang; Fu-Kai Zhang; Ling-Ying Hu; Xing-Quan Zhu
Journal: Front Immunol Date: 2018-06-29 Impact factor: 7.561