| Literature DB >> 19307124 |
Bixue Xu1, Zhengming Huang, Changxiao Liu, Zegui Cai, Weidong Pan, Peixue Cao, Xiaojiang Hao, Guangyi Liang.
Abstract
A series of derivatives of Matijing-Su (MTS, N-(N-benzoyl-L-phenylalanyl)-O-acetyl-L-phenylalanol) was synthesized and evaluated for their anti-hepatitis B virus (HBV) activities in 2.2.15 cells. The IC(50) of compounds 9c (1.40 microM), 9g (2.33 microM) and 9n (2.36 microM), etc. and the selective index of 9n (45.93) of the inhibition on the replication of HBV DNA were higher than those of the positive control lamivudine [41.59, (IC(50): 82.42 microM)]. Compounds 11d, 12a and 12e also exhibited significant anti-HBV activities.Entities:
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Year: 2009 PMID： 19307124 DOI： 10.1016/j.bmc.2009.03.003
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641