| Literature DB >> 19307118 |
Takumi Watanabe1, Isao Momose, Masatoshi Abe, Hikaru Abe, Ryuichi Sawa, Yoji Umezawa, Daishiro Ikeda, Yoshikazu Takahashi, Yuzuru Akamatsu.
Abstract
Boronic acid derivatives of tyropeptin were synthesized with TP-110 as the lead compound. Due to the lability of the aminoboronic acid moiety, careful design of the deprotection and coupling sequence was required. Liquid-liquid partition chromatography was found to be a powerful tool for purification of compounds of this class. The obtained derivatives showed potent inhibitory activities against the human 20S proteasome in vitro.Entities:
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Year: 2009 PMID： 19307118 DOI： 10.1016/j.bmcl.2009.02.117
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823