Literature DB >> 19307115

Discovery of potent and selective DP1 receptor antagonists in the azaindole series.

Yves Leblanc1, Patrick Roy, Claude Dufresne, Nicolas Lachance, Zhaoyin Wang, Gary O'Neill, Gillian Greig, Danielle Denis, Marie-Claude Mathieu, Deborah Slipetz, Nicole Sawyer, Nancy Tsou.   

Abstract

Azaindole based structures were evaluated as DP1 receptor antagonists. This work has lead to the discovery of potent, selective and distinct DP1 receptor antagonists.

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Year:  2009        PMID： 19307115     DOI： 10.1016/j.bmcl.2009.03.010

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease.

Authors:  Naxin Guo; Carolyn J Baglole; Charles W O'Loughlin; Steven E Feldon; Richard P Phipps
Journal:  J Biol Chem       Date:  2010-03-22       Impact factor: 5.157

2.  Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis.

Authors:  Hyang-Yeol Lee; Nancy Yerkes; Sarah E O'Connor
Journal:  Chem Biol       Date:  2009-12-24

3.  Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parameters.

Authors:  Helen Vosper
Journal:  Clin Med Insights Cardiol       Date:  2011-09-19
  3 in total

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