Literature DB >> 1930610

Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors.

D T Wong1, P G Threlkeld, D W Robertson.   

Abstract

The new antidepressant drugs, fluoxetine (and its enantiomers), citalopram, indalpine, paroxetine, and femoxetine show relatively weak affinities for 5-HT receptors as measured by radioligand binding to 5-HT-1(A,B,C and D), 5-HT-2, and 5-HT-3 subtypes. Fluoxetine and R(-)-fluoxetine, at near micromolar concentrations, inhibit 3H-mesulergine binding to 5-HT-1C receptors in bovine choroid plexus, and the R(-) enantiomer is 23 times more potent than the S(+) enantiomer. However, the near nanomolar potencies of these drugs as inhibitors of 5-HT uptake most likely account for their pharmacologic effects in animals.

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Year:  1991        PMID： 1930610

Source DB:  PubMed          Journal:  Neuropsychopharmacology        ISSN： 0893-133X            Impact factor:   7.853


  14 in total

1.  Poster communications.

Authors: 
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739

2.  Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor.

Authors:  E P Pälvimäki; B L Roth; H Majasuo; A Laakso; M Kuoppamäki; E Syvälahti; J Hietala
Journal:  Psychopharmacology (Berl)       Date:  1996-08       Impact factor: 4.530

3.  The effects of paroxetine given repeatedly on the 5-HT receptor subpopulations in the rat brain.

Authors:  J Maj; M Bijak; M Dziedzicka-Wasylewska; R Rogoz; Z Rogóz; G Skuza; T Tokarski
Journal:  Psychopharmacology (Berl)       Date:  1996-09       Impact factor: 4.530

4.  Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac).

Authors:  Y G Ni; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

5.  Modification of behavioral effects of cocaine by selective serotonin and dopamine uptake inhibitors in squirrel monkeys.

Authors:  R D Spealman
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

6.  Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine.

Authors:  E Le Poul; N Laaris; E Doucet; A M Laporte; M Hamon; L Lanfumey
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-08       Impact factor: 3.000

Review 7.  Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in older patients with depressive illness.

Authors:  M G Harris; P Benfield
Journal:  Drugs Aging       Date:  1995-01       Impact factor: 3.923

Review 8.  Antidepressant drug interactions and the cytochrome P450 system. The role of cytochrome P450 2D6.

Authors:  L Ereshefsky; C Riesenman; Y W Lam
Journal:  Clin Pharmacokinet       Date:  1995       Impact factor: 6.447

9.  Differential effects of acute and chronic fluoxetine administration on the spontaneous activity of dopaminergic neurones in the ventral tegmental area.

Authors:  S Prisco; E Esposito
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

10.  Protein kinase C in rat brain cortex and hippocampus: effect of repeated administration of fluoxetine and desipramine.

Authors:  C D Mann; T B Vu; P D Hrdina
Journal:  Br J Pharmacol       Date:  1995-06       Impact factor: 8.739
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