| Literature DB >> 19306055 |
Regislaine Valéria Burim1, Silvia Aparecida Teixeira, Benedicto Oscar Colli, Fernanda Maris Peria, Luis Fernando Tirapelli, Suely Kazue Nagahashi Marie, Suzana Maria Fleury Malheiros, Sueli Mieko Oba-Shinjo, Alberto Alain Gabbai, Paulo Andrade Lotufo, Carlos Gilberto Carlotti-Júnior.
Abstract
Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. The distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.Entities:
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Year: 2009 PMID： 19306055 DOI： 10.1007/s10238-009-0040-6
Source DB: PubMed Journal: Clin Exp Med ISSN： 1591-8890 Impact factor: 3.984