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Literature DB >> 19305946

Preconditioning and its clinical potential.

P Magill¹, T Murphy, D J Bouchier-Hayes, K J Mulhall.

Abstract

Preconditioning is emerging as a simple, safe and highly effective means of attenuating local and systemic effects of medical and surgical insult. Its enormous potential has not yet been harnessed and ongoing work will continue to bring it to the fore. This article covers the history, development and future clinical potential of preconditioning with particular regard to surgical insult.

Mesh：

Year: 2009 PMID： 19305946 DOI： 10.1007/s11845-009-0319-3

Source DB: PubMed Journal: Ir J Med Sci ISSN： 0021-1265 Impact factor: 1.568

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References

65 in total

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Preconditioning and its clinical potential.

1. Diaphragmatic dysfunction secondary to experimental lower torso ischaemia-reperfusion injury is attenuated by thermal preconditioning.

2. Protective effects of ischemic preconditioning on the intestinal mucosal microcirculation following ischemia-reperfusion of the intestine.

3. Adaptation to ischemia during percutaneous transluminal coronary angioplasty. Clinical, hemodynamic, and metabolic features.

4. Renal ischemic preconditioning improves recovery of kidney function and decreases alpha-smooth muscle actin expression in a rat model.

5. Pretreatment with omega-3 fatty acid infusion to prevent leukocyte-endothelial injury responses seen in cardiac surgery.

6. alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.

7. N-acetylcysteine attenuates lung injury in a rodent model of fracture.

8. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs.

9. Induction of heat shock protein 72 prevents neutrophil-mediated human endothelial cell necrosis.

10. Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation.