AIMS: To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls. METHODS AND RESULTS: We performed echocardiography in 44 healthy controls, 35 HCM subjects, 29 DCM subjects with narrow QRS complex (DCM-n), and 27 DCM subjects with wide QRS complex (DCM-w). Mitral annulus velocity (E(a)) and transmitral E-wave velocity were used to estimate time constant of isovolumic pressure decay (tau). LV flow propagation velocity (V(p)) and early intraventricular pressure gradient (IVPG) were derived from colour M-mode of LV inflow. We calculated LV twist and peak untwisting rate (UntwR) by speckle tracking. Mean LV volume/mass ratio was 0.34 +/- 0.09 mL/g in healthy controls, 0.15 +/- 0.06 mL/g in HCM, 0.6 +/- 0.2 mL/g in DCM-n, and 0.8 +/- 0.3 mL/g in DCM-w patients (P < 0.001 for all groups). Resting LV ejection fractions were 63 +/- 7, 64 +/- 8, 31 +/- 8, and 26 +/- 8%, respectively (P < 0.01 vs. controls for DCM groups). In a multivariate analysis, LV volume/mass ratio remained a strong independent predictor of V(p) (P < 0.001), IVPG (P = 0.009), and UntwR (P < 0.001) but not for E(a) (P = 0.25). CONCLUSION: LV volume/mass ratio had influences on diastolic function parameters independent of intrinsic diastolic function and filling pressures. It should be considered when assessing patients suspected of LV diastolic dysfunction.
AIMS: To assess the impact of left ventricular (LV) volume/mass ratio on diastolic function parameters in subjects with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and healthy controls. METHODS AND RESULTS: We performed echocardiography in 44 healthy controls, 35 HCM subjects, 29 DCM subjects with narrow QRS complex (DCM-n), and 27 DCM subjects with wide QRS complex (DCM-w). Mitral annulus velocity (E(a)) and transmitral E-wave velocity were used to estimate time constant of isovolumic pressure decay (tau). LV flow propagation velocity (V(p)) and early intraventricular pressure gradient (IVPG) were derived from colour M-mode of LV inflow. We calculated LV twist and peak untwisting rate (UntwR) by speckle tracking. Mean LV volume/mass ratio was 0.34 +/- 0.09 mL/g in healthy controls, 0.15 +/- 0.06 mL/g in HCM, 0.6 +/- 0.2 mL/g in DCM-n, and 0.8 +/- 0.3 mL/g in DCM-w patients (P < 0.001 for all groups). Resting LV ejection fractions were 63 +/- 7, 64 +/- 8, 31 +/- 8, and 26 +/- 8%, respectively (P < 0.01 vs. controls for DCM groups). In a multivariate analysis, LV volume/mass ratio remained a strong independent predictor of V(p) (P < 0.001), IVPG (P = 0.009), and UntwR (P < 0.001) but not for E(a) (P = 0.25). CONCLUSION:LV volume/mass ratio had influences on diastolic function parameters independent of intrinsic diastolic function and filling pressures. It should be considered when assessing patients suspected of LV diastolic dysfunction.
Authors: Yuichi Notomi; Peter Lysyansky; Randolph M Setser; Takahiro Shiota; Zoran B Popović; Maureen G Martin-Miklovic; Joan A Weaver; Stephanie J Oryszak; Neil L Greenberg; Richard D White; James D Thomas Journal: J Am Coll Cardiol Date: 2005-06-21 Impact factor: 24.094
Authors: Zoran B Popović; Jing Ping Sun; Hirotsugu Yamada; Jeannie Drinko; Karin Mauer; Neil L Greenberg; Yuanna Cheng; Christine S Moravec; Marc S Penn; Todor N Mazgalev; James D Thomas Journal: J Physiol Date: 2005-07-07 Impact factor: 5.182
Authors: Richard W Troughton; David L Prior; Christopher M Frampton; Patrick J Nash; Jeremy J Pereira; Maureen Martin; Annette Fogarty; Annitta J Morehead; Randall C Starling; James B Young; James D Thomas; Michael S Lauer; Allan L Klein Journal: Am J Cardiol Date: 2005-07-15 Impact factor: 2.778
Authors: Graeme Carrick-Ranson; Jeffrey L Hastings; Paul S Bhella; Shigeki Shibata; Naoki Fujimoto; M Dean Palmer; Kara Boyd; Benjamin D Levine Journal: Am J Physiol Heart Circ Physiol Date: 2012-06-01 Impact factor: 4.733
Authors: Bee Ting Chan; Noor Azuan Abu Osman; Einly Lim; Kok Han Chee; Yang Faridah Abdul Aziz; Amr Al Abed; Nigel H Lovell; Socrates Dokos Journal: PLoS One Date: 2013-06-25 Impact factor: 3.240
Authors: Wael A Aljaroudi; Milind Y Desai; M Chadi Alraies; Maran Thamilarasan; Venu Menon; L Leonardo Rodriguez; Nicholas Smedira; Richard A Grimm; Harry M Lever; Wael A Jaber Journal: BMJ Open Date: 2012-12-12 Impact factor: 2.692
Authors: Regis R Lamberts; Shivanjali J Lingam; Heng-Yu Wang; Ilse A E Bollen; Gillian Hughes; Ivor F Galvin; Richard W Bunton; Andrew Bahn; Rajesh Katare; J Chris Baldi; Michael J A Williams; Pankaj Saxena; Sean Coffey; Peter P Jones Journal: Cardiovasc Diabetol Date: 2014-04-05 Impact factor: 9.951