OBJECTIVES: To identify predictors of success for an 8week pulmonary rehabilitation programme (PRP) in patients with chronic obstructive pulmonary disease (COPD). METHODS: Sixty patients were stratified in subgroups according to baseline findings: airway obstruction (FEV(1) >/= or <50% pred), pulmonary hyperinflation (TLC > or <or=120% pred), BMI value (BMI > or <or=25), cardiovascular (CV) comorbidity, and resting PaO(2) (PaO(2) >/= or <60mmHg). Outcome measurements of PRP were: >54m increase in 6min walking test (6MWT), or >4points reduction in total score of S. George Respiratory Questionnaire (SGRQ). Logistic regression analysis was used. RESULTS: After PRP there was a significant improvement in exercise tolerance and quality of life, which correlated with baseline FEV(1)/VC, PaO(2), SpO(2), 6MWT and SGRQ. SGRQ significantly decreased and 6MWT significantly increased after PRP in all subgroups, except for patients with CV comorbidities. Both univariate and multivariate logistic regression analyses showed that BMI>25 and resting PaO(2)<60mmHg were independent predictors of PRP efficacy in terms of improvement of 6MWT, but not of SGRQ scores. CONCLUSIONS: Clinical and functional baseline findings do not predict the response to PRP in COPD. The greater efficacy in patients with BMI>25 or with PaO(2)<60mmHg may be due to a greater deconditioning in overweight patients, and to a larger room for improvement in hypoxemic patients.
OBJECTIVES: To identify predictors of success for an 8week pulmonary rehabilitation programme (PRP) in patients with chronic obstructive pulmonary disease (COPD). METHODS: Sixty patients were stratified in subgroups according to baseline findings: airway obstruction (FEV(1) >/= or <50% pred), pulmonary hyperinflation (TLC > or <or=120% pred), BMI value (BMI > or <or=25), cardiovascular (CV) comorbidity, and resting PaO(2) (PaO(2) >/= or <60mmHg). Outcome measurements of PRP were: >54m increase in 6min walking test (6MWT), or >4points reduction in total score of S. George Respiratory Questionnaire (SGRQ). Logistic regression analysis was used. RESULTS: After PRP there was a significant improvement in exercise tolerance and quality of life, which correlated with baseline FEV(1)/VC, PaO(2), SpO(2), 6MWT and SGRQ. SGRQ significantly decreased and 6MWT significantly increased after PRP in all subgroups, except for patients with CV comorbidities. Both univariate and multivariate logistic regression analyses showed that BMI>25 and resting PaO(2)<60mmHg were independent predictors of PRP efficacy in terms of improvement of 6MWT, but not of SGRQ scores. CONCLUSIONS: Clinical and functional baseline findings do not predict the response to PRP in COPD. The greater efficacy in patients with BMI>25 or with PaO(2)<60mmHg may be due to a greater deconditioning in overweight patients, and to a larger room for improvement in hypoxemic patients.
Authors: Pervin Korkmaz Ekren; Alev Gürgün; Funda Elmas Uysal; Şenay Tuncel; Sami Deniz; Hale Karapolat; Feza Bacakoğlu Journal: Turk J Phys Med Rehabil Date: 2018-05-23
Authors: Afroditi K Boutou; Rebecca J Tanner; Victoria M Lord; Lauren Hogg; Jane Nolan; Helen Jefford; Evelyn J Corner; Christine Falzon; Cassandra Lee; Rachel Garrod; Michael I Polkey; Nicholas S Hopkinson Journal: BMJ Open Respir Res Date: 2014-11-03
Authors: Nini H Jonkman; Heleen Westland; Jaap Ca Trappenburg; Rolf Hh Groenwold; Erik Wma Bischoff; Jean Bourbeau; Christine E Bucknall; David Coultas; Tanja W Effing; Michael J Epton; Frode Gallefoss; Judith Garcia-Aymerich; Suzanne M Lloyd; Evelyn M Monninkhof; Huong Q Nguyen; Job van der Palen; Kathryn L Rice; Maria Sedeno; Stephanie Jc Taylor; Thierry Troosters; Nicholas A Zwar; Arno W Hoes; Marieke J Schuurmans Journal: Int J Chron Obstruct Pulmon Dis Date: 2016-08-31