How to identify new genetic risk factors for VTE?

Venous thrombosis is a common and complex disease in which genetic risk factors play a major role. At present 6 strong and about 20 weak genetic risk factors are known. Family and twin studies indicate that additional genetic risk factors remain to be identified in order to explain the full extent of the known heritability. This short narrative review discusses several of the approaches which can be taken to identify new risk factors that predispose to venous thrombosis.