OBJECTIVE: While the relation between alcohol consumption and mortality has been well explored, little is known about the link between alcohol problems and mortality in general population-based studies, particularly among women. This was the objective of the present study METHODS: In this prospective cohort study, 5333 non-abstaining individuals (2539 women) from the UK-wide Health and Lifestyle Survey (aged 42.9 years at study induction) completed the CAGE questionnaire of alcohol problems and participated in a medical examination in 1984/1985; they were then followed up for mortality experience until 2005. RESULTS: Alcohol problems at baseline were less common in women (2.4%) than in men (7.8%). A total of 21 years of follow-up gave rise to 1201 deaths. Elevated rates of mortality were evident in persons reporting symptoms of alcohol problems in comparison to those who did not. In gender-stratified analyses, alcohol problems were more strongly associated with mortality risk in women (age-adjusted hazards ratio: 2.25; 95% confidence interval: 1.22-4.12) than in men (1.49; 1.12-1.99), although this effect modification was not statistically significant (P value for interaction=0.125). Controlling for a range of covariates--including socioeconomic position, co-morbidity (somatic and psychiatric), and alcohol intake--had essentially no impact on these associations. CONCLUSION: The CAGE questionnaire may have some utility in routine health assessments in the general population.
OBJECTIVE: While the relation between alcohol consumption and mortality has been well explored, little is known about the link between alcohol problems and mortality in general population-based studies, particularly among women. This was the objective of the present study METHODS: In this prospective cohort study, 5333 non-abstaining individuals (2539 women) from the UK-wide Health and Lifestyle Survey (aged 42.9 years at study induction) completed the CAGE questionnaire of alcohol problems and participated in a medical examination in 1984/1985; they were then followed up for mortality experience until 2005. RESULTS:Alcohol problems at baseline were less common in women (2.4%) than in men (7.8%). A total of 21 years of follow-up gave rise to 1201 deaths. Elevated rates of mortality were evident in persons reporting symptoms of alcohol problems in comparison to those who did not. In gender-stratified analyses, alcohol problems were more strongly associated with mortality risk in women (age-adjusted hazards ratio: 2.25; 95% confidence interval: 1.22-4.12) than in men (1.49; 1.12-1.99), although this effect modification was not statistically significant (P value for interaction=0.125). Controlling for a range of covariates--including socioeconomic position, co-morbidity (somatic and psychiatric), and alcohol intake--had essentially no impact on these associations. CONCLUSION: The CAGE questionnaire may have some utility in routine health assessments in the general population.
Authors: Alex H S Harris; Katharine A Bradley; Thomas Bowe; Patricia Henderson; Rudolf Moos Journal: Popul Health Manag Date: 2010-10 Impact factor: 2.459
Authors: M Virtanen; J E Ferrie; A Singh-Manoux; M J Shipley; S A Stansfeld; M G Marmot; K Ahola; J Vahtera; M Kivimäki Journal: Psychol Med Date: 2011-02-18 Impact factor: 7.723
Authors: Clare J Wilhelm; Joel G Hashimoto; Melissa L Roberts; Shelley H Bloom; Douglas K Beard; Kristine M Wiren Journal: Brain Res Date: 2015-01-16 Impact factor: 3.252
Authors: G David Batty; Abita Bhaskar; Carol Emslie; Michaela Benzeval; Geoff Der; Heather Lewars; Kate Hunt Journal: Int J Public Health Date: 2011-07-03 Impact factor: 3.380
Authors: Karolina Agur; Gary McLean; Kate Hunt; Bruce Guthrie; Stewart W Mercer Journal: Int J Environ Res Public Health Date: 2016-03-31 Impact factor: 3.390