Literature DB >> 19302789

Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol.

Anne-Marie Marzesco1, Michaela Wilsch-Bräuninger, Véronique Dubreuil, Peggy Janich, Katja Langenfeld, Christoph Thiele, Wieland B Huttner, Denis Corbeil.   

Abstract

We previously reported on the occurrence of prominin-1-carrying membrane vesicles that are released into body fluids from microvilli of epithelial cells. This release has been implicated in cell differentiation. Here we have characterized these vesicles released from the differentiated Caco-2 cells. We find that in these vesicles, prominin-1 directly interacts with membrane cholesterol and is associated with a membrane microdomain. The cholesterol depletion using methyl-beta-cyclodextrin resulted in a marked increase in their release, and a dramatic change in the microvillar ultrastructure from a tubular shape to a "pearling" state, with multiple membrane constrictions, suggesting a role of membrane cholesterol in vesicle release from microvilli.

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Year:  2009        PMID： 19302789     DOI： 10.1016/j.febslet.2009.01.048

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  23 in total

1.  Prominin-2 is a novel marker of distal tubules and collecting ducts of the human and murine kidney.

Authors:  József Jászai; Lilla M Farkas; Christine A Fargeas; Peggy Janich; Michael Haase; Wieland B Huttner; Denis Corbeil
Journal:  Histochem Cell Biol       Date:  2010-03-24       Impact factor: 4.304

2.  Altered folate binding protein expression and folate delivery are associated with congenital hydrocephalus in the hydrocephalic Texas rat.

Authors:  Alicia Requena Jimenez; Naila Naz; Jaleel A Miyan
Journal:  J Cereb Blood Flow Metab       Date:  2018-05-25       Impact factor: 6.200

3.  Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels.

Authors:  Bing-Chen Liu; Li-Li Yang; Xiao-Yu Lu; Xiang Song; Xue-Chen Li; Guangping Chen; Yichao Li; Xincheng Yao; Donald R Humphrey; Douglas C Eaton; Bao-Zhong Shen; He-Ping Ma
Journal:  J Am Soc Nephrol       Date:  2014-10-27       Impact factor: 10.121

4.  CD133 and membrane microdomains: old facets for future hypotheses.

Authors:  Christine A Fargeas; Jana Karbanová; József Jászai; Denis Corbeil
Journal:  World J Gastroenterol       Date:  2011-09-28       Impact factor: 5.742

5.  Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.

Authors:  Tiane Chen; Ann Hubbard; Rakhilya Murtazina; Jennifer Price; Jianbo Yang; Boyoung Cha; Rafiquel Sarker; Mark Donowitz
Journal:  J Cell Sci       Date:  2014-06-13       Impact factor: 5.285

6.  Prominin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosis.

Authors:  Raman Deep Singh; Andreas S Schroeder; Luana Scheffer; Eileen L Holicky; Christine L Wheatley; David L Marks; Richard E Pagano
Journal:  Biochem Biophys Res Commun       Date:  2013-04-10       Impact factor: 3.575

7.  Cholesterol efflux stimulates metalloproteinase-mediated cleavage of occludin and release of extracellular membrane particles containing its C-terminal fragments.

Authors:  Elizabeth Casas; Cory Barron; Stacy A Francis; Joanne M McCormack; Karin M McCarthy; Eveline E Schneeberger; Robert D Lynch
Journal:  Exp Cell Res       Date:  2009-10-23       Impact factor: 3.905

8.  CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.

Authors:  Kathrin Arndt; Tatyana Grinenko; Nicole Mende; Doreen Reichert; Melanie Portz; Tatsiana Ripich; Peter Carmeliet; Denis Corbeil; Claudia Waskow
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-18       Impact factor: 11.205

9.  Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3.

Authors:  József Jászai; Kristina Thamm; Jana Karbanová; Peggy Janich; Christine A Fargeas; Wieland B Huttner; Denis Corbeil
Journal:  J Biol Chem       Date:  2020-03-22       Impact factor: 5.157

10.  Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.

Authors:  Kanako Saito; Veronique Dubreuil; Yoko Arai; Michaela Wilsch-Bräuninger; Dominik Schwudke; Gesine Saher; Takaki Miyata; Georg Breier; Christoph Thiele; Andrej Shevchenko; Klaus-Armin Nave; Wieland B Huttner
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-05       Impact factor: 11.205
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