Literature DB >> 1930242

In vivo activation of an omega-6 oxygenase in human skin.

A N Baer1, P B Costello, F A Green.   

Abstract

To test the hypothesis that an epidermal fatty acid oxygenase is activated in vivo under physiologic conditions, surface lipids from normal human skin were analyzed for oxygenase products. With high-performance liquid chromatography on reversed-phase and straight-phase chiral columns and gas-liquid chromatography/mass spectrometry, these lipids were found to contain free 13-hydroxyoctadeca-9Z,11E-dienoic acid and 9-hydroxyoctadeca-10E,12Z-dienoic acid. The 13-hydroxyoctadecadienoic acid was present as a stereoisomeric mixture, with an average S/R ratio of 2.2, and exceeded the concentration of 9-hydroxyoctadecadienoic acid by a factor of 2. These observations and others indicate that the 13-hydroxyoctadecadienoic acid was derived mostly from an omega-6 oxygenase (probably 15-lipoxygenase) which is activated in vivo in normal skin.

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Year:  1991        PMID： 1930242     DOI： 10.1016/s0006-291x(05)81260-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

Review 1.  15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?

Authors:  Sun Il Lee; Xiangsheng Zuo; Imad Shureiqi
Journal:  Cancer Metastasis Rev       Date:  2011-12       Impact factor: 9.264

Review 2.  ALOX15 as a suppressor of inflammation and cancer: Lost in the link.

Authors:  Rui Tian; Xiangsheng Zuo; Jonathan Jaoude; Fei Mao; Jennifer Colby; Imad Shureiqi
Journal:  Prostaglandins Other Lipid Mediat       Date:  2017-01-13       Impact factor: 3.072

3.  Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1.

Authors:  Masoumeh Tavakoli-Yaraki; Fatemeh Karami-Tehrani; Vahid Salimi; Majid Sirati-Sabet
Journal:  Tumour Biol       Date:  2012-10-06

Review 4.  The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer.

Authors:  Fei Mao; Mei Wang; Juanjuan Wang; Wen-Rong Xu
Journal:  Inflamm Res       Date:  2015-07-21       Impact factor: 4.575

5.  Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells.

Authors:  Xiangsheng Zuo; Jeffrey S Morris; Imad Shureiqi
Journal:  J Biol Chem       Date:  2008-09-17       Impact factor: 5.157

6.  Inhibitory effects of sulfonated shale oils (ammonium bituminosulphonates, Ichthyols) on enzymes of polyenoic fatty acid metabolism.

Authors:  C Schewe; T Schewe; E Rohde; W Diezel; B M Czarnetzki
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017

7.  15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation.

Authors:  Xiangsheng Zuo; Lanlan Shen; Jean-Pierre Issa; Ofir Moy; Jeffrey S Morris; Scott M Lippman; Imad Shureiqi
Journal:  FASEB J       Date:  2008-01-15       Impact factor: 5.191

8.  15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells.

Authors:  X Zuo; J S Morris; R Broaddus; I Shureiqi
Journal:  Oncogene       Date:  2009-02-09       Impact factor: 9.867

9.  The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms.

Authors:  Mohammad Alsalem; Amy Wong; Paul Millns; Pallavi Huma Arya; Michael Siang Liang Chan; Andrew Bennett; David A Barrett; Victoria Chapman; David A Kendall
Journal:  Br J Pharmacol       Date:  2013-04       Impact factor: 8.739

10.  The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function: IMPLICATION OF AN EPOXIDE HYDROLASE IN THE TRANSFORMATIONS OF LINOLEATE.

Authors:  Takahito Chiba; Christopher P Thomas; M Wade Calcutt; William E Boeglin; Valerie B O'Donnell; Alan R Brash
Journal:  J Biol Chem       Date:  2016-05-05       Impact factor: 5.157
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