Literature DB >> 1930227

Neutrophil activating peptide-2 binds with two affinities to receptor(s) on human neutrophils.

W Schnitzel1, B Garbeis, U Monschein, J Besemer.   

Abstract

Neutrophil receptor(s) for neutrophil activating peptides 1 and 2 were studied by competition binding experiments with radiolabeled NAP-1 and NAP-2 preparations. NAP-1 bound with one affinity, NAP-2 with two quite different affinities, to common receptor(s) on neutrophils. Concentrations of NAP-2 needed to induce exocytosis of beta-glucosaminidase corresponded to the higher dissociation constant of the two binding equilibria. Thus, the binding of NAP-2 to PMN with high affinity does not activate the cells.

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Year:  1991        PMID： 1930227     DOI： 10.1016/s0006-291x(05)81292-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

1.  Secondary structure of neutrophil-activating peptide-2 determined by 1H-nuclear magnetic resonance spectroscopy.

Authors:  K H Mayo; Y Yang; T J Daly; J K Barry; G J La Rosa
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

2.  NMR structure and dynamics of monomeric neutrophil-activating peptide 2.

Authors:  H Young; V Roongta; T J Daly; K H Mayo
Journal:  Biochem J       Date:  1999-03-15       Impact factor: 3.857

3.  Biological activity of the growth factor-induced cytokine N51: structure-function analysis using N51/Interleukin-8 chimeric molecules.

Authors:  J N Heinrich; E C O'Rourke; L Chen; H Gray; K S Dorfman; R Bravo
Journal:  Mol Cell Biol       Date:  1994-05       Impact factor: 4.272

4.  Expression of transcripts for two interleukin 8 receptors in human phagocytes, lymphocytes and melanoma cells.

Authors:  B Moser; L Barella; S Mattei; C Schumacher; F Boulay; M P Colombo; M Baggiolini
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857
  4 in total

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