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Literature DB >> 1930151

Expression of epidermal growth factor and its mRNA in pig kidney, pancreas and other tissues.

T J Vaughan¹, J C Pascall, P S James, K D Brown.

Abstract

The levels of epidermal growth factor (EGF) mRNA in a wide range of pig tissues were measured by a RNAase-protection assay. The highest levels were found in kidney and pancreas, with lower levels in submaxillary gland, prostate gland and seminal vesicles. Immunocytochemical staining using an antiserum raised against recombinant pig EGF localized expression of the factor to the distal convoluted tubules of the kidney and to the epithelial cells lining the pancreatic and salivary ducts. The observed expression of EGF mRNA and EGF in pig tissues is consistent with a possible role for EGF in the maintenance and repair of the epithelial lining of various ductal systems.

Entities: Disease Gene Species

Mesh：

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Year: 1991 PMID： 1930151 PMCID： PMC1151583 DOI： 10.1042/bj2790315

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

21 in total

1. Urogastrone-epidermal growth factor concentrations in prostatic fluid of normal individuals and patients with benign prostatic hypertrophy.

Authors: H Gregory; I R Willshire; J P Kavanagh; N J Blacklock; S Chowdury; R C Richards
Journal: Clin Sci (Lond) Date: 1986-04 Impact factor: 6.124

2. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Authors: D A Melton; P A Krieg; M R Rebagliati; T Maniatis; K Zinn; M R Green
Journal: Nucleic Acids Res Date: 1984-09-25 Impact factor: 16.971

3. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1983-07-01 Impact factor: 3.365

4. Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer.

Authors: C M Barton; P A Hall; C M Hughes; W J Gullick; N R Lemoine
Journal: J Pathol Date: 1991-02 Impact factor: 7.996

5. Immunoreactive human epidermal growth factor in human pancreatic juice.

Authors: Y Hirata; M Uchihashi; M Nakajima; T Fujita; S Matsukura
Journal: J Clin Endocrinol Metab Date: 1982-06 Impact factor: 5.958

6. Immunocytochemical localization of epidermal growth factor during the postnatal development of the submandibular gland of the mouse.

Authors: E W Gresik; T Barka
Journal: Am J Anat Date: 1978-01

7. Human beta-nerve growth factor gene sequence highly homologous to that of mouse.

Authors: A Ullrich; A Gray; C Berman; T J Dull
Journal: Nature Date: 1983-06-30 Impact factor: 49.962

8. Chromosomal locations of the human and mouse genes for precursors of epidermal growth factor and the beta subunit of nerve growth factor.

Authors: B U Zabel; R L Eddy; P A Lalley; J Scott; G I Bell; T B Shows
Journal: Proc Natl Acad Sci U S A Date: 1985-01 Impact factor: 11.205

9. Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues.

Authors: L B Rall; J Scott; G I Bell; R J Crawford; J D Penschow; H D Niall; J P Coghlan
Journal: Nature Date: 1985 Jan 17-23 Impact factor: 49.962

10. Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.

Authors: G I Bell; N M Fong; M M Stempien; M A Wormsted; D Caput; L L Ku; M S Urdea; L B Rall; R Sanchez-Pescador
Journal: Nucleic Acids Res Date: 1986-11-11 Impact factor: 16.971

5 in total

1. Species differences in the expression of transforming growth factor-alpha (TGF-alpha) in the submandibular gland and pancreas.

Authors: Y Ikematsu; P M Pour; K Kazakoff
Journal: Int J Pancreatol Date: 1997-10

5. Chronic systemic treatment with epidermal growth factor in pigs causes pronounced urothelial growth with accumulation of glycoconjugates.

Authors: L Vinter-Jensen; C O Juhl; J C Djurhuus; S S Poulsen; E Z Dajani; K D Brown; T F Orntoft; P S Teglbjaerg; E Nexø
Journal: Am J Pathol Date: 1995-11 Impact factor: 4.307